Novel factor XIII probes for blood coagulation imaging

Ching Hsuan Tung; Nan Hui Ho; Qing Zeng; Yi Tang; Farouc A. Jaffer; Guy L. Reed; Ralph Weissleder

doi:10.1002/cbic.200300602

Novel factor XIII probes for blood coagulation imaging

Ching Hsuan Tung, Nan Hui Ho, Qing Zeng, Yi Tang, Farouc A. Jaffer, Guy L. Reed, Ralph Weissleder

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

The clot thickens: An α2-antiplasmin peptide fragment labeled with a near-infrared fluorochrome or a paramagnetic reporter (see figure) can be used for imaging blood clot formation. A thrombosis-specific probe was developed based on blood coagulation factor XIII transglutaminase but the approach could be extended to other transglutaminases involved in diseases such as cancer, neurodegenerative diseases and celiac disease. The use of near-infrared fluorescence avoids the difficulty of background absorbance encountered when light imaging is used for blood imaging.

Original language	English (US)
Pages (from-to)	897-899
Number of pages	3
Journal	ChemBioChem
Volume	4
Issue number	9
DOIs	https://doi.org/10.1002/cbic.200300602
State	Published - Sep 5 2003
Externally published	Yes

Keywords

Blood coagulation
Factor 13
Fluorescent probes
Imaging agents
Transglutaminase

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Organic Chemistry

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10.1002/cbic.200300602

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abstract = "The clot thickens: An α2-antiplasmin peptide fragment labeled with a near-infrared fluorochrome or a paramagnetic reporter (see figure) can be used for imaging blood clot formation. A thrombosis-specific probe was developed based on blood coagulation factor XIII transglutaminase but the approach could be extended to other transglutaminases involved in diseases such as cancer, neurodegenerative diseases and celiac disease. The use of near-infrared fluorescence avoids the difficulty of background absorbance encountered when light imaging is used for blood imaging.",

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AU - Tung, Ching Hsuan

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AU - Zeng, Qing

AU - Tang, Yi

AU - Jaffer, Farouc A.

AU - Reed, Guy L.

AU - Weissleder, Ralph

PY - 2003/9/5

Y1 - 2003/9/5

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AB - The clot thickens: An α2-antiplasmin peptide fragment labeled with a near-infrared fluorochrome or a paramagnetic reporter (see figure) can be used for imaging blood clot formation. A thrombosis-specific probe was developed based on blood coagulation factor XIII transglutaminase but the approach could be extended to other transglutaminases involved in diseases such as cancer, neurodegenerative diseases and celiac disease. The use of near-infrared fluorescence avoids the difficulty of background absorbance encountered when light imaging is used for blood imaging.

KW - Blood coagulation

KW - Factor 13

KW - Fluorescent probes

KW - Imaging agents

KW - Transglutaminase

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Novel factor XIII probes for blood coagulation imaging

Abstract

Keywords

ASJC Scopus subject areas

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