Novel factor XIII probes for blood coagulation imaging

Ching Hsuan Tung, Nan Hui Ho, Qing Zeng, Yi Tang, Farouc A. Jaffer, Guy L. Reed, Ralph Weissleder

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

The clot thickens: An α2-antiplasmin peptide fragment labeled with a near-infrared fluorochrome or a paramagnetic reporter (see figure) can be used for imaging blood clot formation. A thrombosis-specific probe was developed based on blood coagulation factor XIII transglutaminase but the approach could be extended to other transglutaminases involved in diseases such as cancer, neurodegenerative diseases and celiac disease. The use of near-infrared fluorescence avoids the difficulty of background absorbance encountered when light imaging is used for blood imaging.

Original languageEnglish (US)
Pages (from-to)897-899
Number of pages3
JournalChemBioChem
Volume4
Issue number9
DOIs
StatePublished - Sep 5 2003
Externally publishedYes

Keywords

  • Blood coagulation
  • Factor 13
  • Fluorescent probes
  • Imaging agents
  • Transglutaminase

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

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