@inproceedings{7c9b8ebaf9384f0fa18c6ae5120b0f87,
title = "Novel extrusion system for the encapsulation of drug releasing bio-medical micro-robots",
abstract = "This paper examines the design and testing of a novel extrusion system for the biocompatible coating of drug delivering micro-robots. The encapsulation system creates monodisperse droplets of sodium alginate containing the micro-robots within a coaxial laminar flow of a continuous oil phase. The extrusion process allows the experimenter to control the size of the drug carrying droplets which have been subsequently tested as vehicles to deliver a model drug (Horseradish peroxidase). Comparison with other coating techniques such as dip-coating shows significant increase in the drug storing capacity. A demonstration of the use of ultrasound as a possible trigger of the drug release has also been presented. The significant increase in the observed drug release rate shows enhancement over previously tested passive diffusion and magnetic modulation methods. Together, these two aspects of micro-robotic drug delivery concept introduce a new approach to drug-delivering microrobots with large drug-storage capacity, ability to propel the robots using magnetic forces, and trigger the drugrelease by remote application of ultrasonic stimulation.",
author = "Enikov, {Eniko T.} and Gibson, {Malcolm T.} and Ritty, {Stephane J.}",
year = "2009",
doi = "10.1109/ICCME.2009.4906603",
language = "English (US)",
isbn = "9781424433162",
series = "2009 ICME International Conference on Complex Medical Engineering, CME 2009",
publisher = "IEEE Computer Society",
booktitle = "2009 ICME International Conference on Complex Medical Engineering, CME 2009",
note = "2009 ICME International Conference on Complex Medical Engineering, CME 2009 ; Conference date: 09-04-2009 Through 11-04-2009",
}