Novel assessment of leukocyte-rich platelet-rich plasma on functional and patient-reported outcomes in knee osteoarthritis: A pilot study

Prathap Jayaram, Gu Eon Kang, Brett L. Heldt, Olumide Sokunbi, Bo Song, Peter C. Yeh, Max Epstein, Theodore B. Shybut, Brendan H. Lee, Bijan Najafi

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background: Leukocyte-rich platelet-rich plasma (LR-PRP) has demonstrated to be beneficial for patients with knee osteoarthritis (KOA); however, reliable objective end points to accurately assess its therapeutic effects is lacking. Aim: To investigate the efficacy of LR-PRP as assessed by functional and patient-reported outcomes at early time points (6 weeks). Materials & methods: We conducted a prospective cohort study in 12 patients with diagnosed KOA (Kellgren Lawrence score of II-III), who underwent a single ultrasound-guided LR-PRP injection. Results: There was significant improvement in timed up and go, pain and quality of life scales and balance parameters. There were nonsignificant improvements in range of motion and gait parameters. Conclusion: LR-PRP demonstrates efficacy in meaningful end points for functional and patient-reported outcomes at early time points in patients with KOA.

Original languageEnglish (US)
Pages (from-to)823-832
Number of pages10
JournalRegenerative Medicine
Volume16
Issue number9
DOIs
StatePublished - Sep 2021
Externally publishedYes

Keywords

  • balance
  • functional outcomes
  • gait
  • knee injury and osteoarthritis outcome score 12
  • knee osteoarthritis
  • leukocyte-rich platelet-rich plasma
  • patient-reported outcomes
  • timed up and go
  • wearable sensor technology

ASJC Scopus subject areas

  • Biomedical Engineering
  • Embryology

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