Abstract
This letter describes novel high-yielding solution phase preparations of 1,4-benzodiazepine-2,5-dione, diketopiperazine, ketopiperazine and dihydroquinoxalinone libraries via a UDC (Ugi/de-Boc/cyclization) strategy in combination with ethylglyoxalate. The methodology represents a 'three step, one-pot procedure', employing the Ugi multi-component reaction (MCR), followed by Boc deprotection and cyclization.
Original language | English (US) |
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Pages (from-to) | 5295-5299 |
Number of pages | 5 |
Journal | Tetrahedron Letters |
Volume | 40 |
Issue number | 29 |
DOIs | |
State | Published - Jul 16 1999 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry