Novel applications of ethyl glyoxalate with the Ugi MCR

Christopher Hulme; M. P. Cherrier

doi:10.1016/S0040-4039(99)00960-0

Novel applications of ethyl glyoxalate with the Ugi MCR

Christopher Hulme, M. P. Cherrier

Research output: Contribution to journal › Article › peer-review

128 Scopus citations

Abstract

This letter describes novel high-yielding solution phase preparations of 1,4-benzodiazepine-2,5-dione, diketopiperazine, ketopiperazine and dihydroquinoxalinone libraries via a UDC (Ugi/de-Boc/cyclization) strategy in combination with ethylglyoxalate. The methodology represents a 'three step, one-pot procedure', employing the Ugi multi-component reaction (MCR), followed by Boc deprotection and cyclization.

Original language	English (US)
Pages (from-to)	5295-5299
Number of pages	5
Journal	Tetrahedron Letters
Volume	40
Issue number	29
DOIs	https://doi.org/10.1016/S0040-4039(99)00960-0
State	Published - Jul 16 1999
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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abstract = "This letter describes novel high-yielding solution phase preparations of 1,4-benzodiazepine-2,5-dione, diketopiperazine, ketopiperazine and dihydroquinoxalinone libraries via a UDC (Ugi/de-Boc/cyclization) strategy in combination with ethylglyoxalate. The methodology represents a 'three step, one-pot procedure', employing the Ugi multi-component reaction (MCR), followed by Boc deprotection and cyclization.",

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AB - This letter describes novel high-yielding solution phase preparations of 1,4-benzodiazepine-2,5-dione, diketopiperazine, ketopiperazine and dihydroquinoxalinone libraries via a UDC (Ugi/de-Boc/cyclization) strategy in combination with ethylglyoxalate. The methodology represents a 'three step, one-pot procedure', employing the Ugi multi-component reaction (MCR), followed by Boc deprotection and cyclization.

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Novel applications of ethyl glyoxalate with the Ugi MCR

Abstract

ASJC Scopus subject areas

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