Novel agents and evolving strategies in myelofibrotive neoplasm: an update from 2022 ASH annual conference

Andrew Wang, James Liu, Jeffrey J. Pu

Research output: Contribution to journalLetterpeer-review

Abstract

Myelofibrosis (MF) is a disorder characterized by the proliferation of myeloid precursors, commonly due to overactive JAK signaling. The discovery of the JAK2V617F mutation and subsequent development of JAK inhibitors (JAKi) results in reduced spleen size, improved symptom, and enhanced survival in MF patients. However, there are unmet needs of additional novel targeted therapies for this incurable disease due to the limited utility of first-generation JAKis, which are associated with dose-limiting cytopenia and disease recurrence. New targeted treatment strategies for MF are on the horizon. We are here to discuss the latest clinical research findings presented in the 2022 ASH Annual Meeting.

Original languageEnglish (US)
Article number53
JournalJournal of Hematology and Oncology
Volume16
Issue number1
DOIs
StatePublished - Dec 2023
Externally publishedYes

Keywords

  • Clinical research
  • Myelofibrotive neoplasm
  • Targeted therapy

ASJC Scopus subject areas

  • Hematology
  • Molecular Biology
  • Oncology
  • Cancer Research

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