Not all traumatic brain injury patients on preinjury anticoagulation are the same

BIG Multi-institutional Study Group, The American Association for the Surgery of Trauma Brain Injury Guidelines Multi-institutional Study Group

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Background: Prognostic significance of different anticoagulants in TBI patients remains unanswered. We aimed to compare effects of different anticoagulants on outcomes of TBI patients. Methods: A secondary analysis of AAST BIG MIT. Blunt TBI patients ≥50 years using anticoagulants presenting ICH were identified. Outcomes were progression of ICH and need for neurosurgical intervention (NSI). Results: 393 patients were identified. Mean age was 74 and most common anticoagulant was aspirin (30%), followed by Plavix (28%), and coumadin (20%). 20% had progression of ICH and 10% underwent NSI. On multivariate regression for ICH progression, warfarin, SDH, IPH, SAH, alcohol intoxication and neurologic exam deterioration were associated with increased odds. Warfarin, abnormal neurologic exam on presentation, and SDH were independent predictors of NSI. Conclusions: Our findings reflect a dynamic interaction between type of anticoagulants, bleeding pattern & outcomes. Future modifications of BIG may need to take the type of anticoagulant into consideration.

Original languageEnglish (US)
JournalAmerican journal of surgery
StateAccepted/In press - 2023
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


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