Noninteraction of Digitoxin and Quinidine

Kenneth R. Melvin; Robert E. Kates; Douglas E. Rollins; Moshe Garty; Paul E. Fenster; Frank I. Marcus; Kenneth Conrad; Penelope E. Graves; W. David Hager; J. Robert Powell; Hermann R. Ochs; David J. Greenblatt

doi:10.1056/NEJM198101083040215

Noninteraction of Digitoxin and Quinidine

Kenneth R. Melvin, Robert E. Kates, Douglas E. Rollins, Moshe Garty, Paul E. Fenster, Frank I. Marcus, Kenneth Conrad, Penelope E. Graves, W. David Hager, J. Robert Powell, Hermann R. Ochs, David J. Greenblatt

Medicine

Research output: Contribution to journal › Letter › peer-review

2 Scopus citations

Abstract

To the Editor: The study design employed by Ochs et al. in their article in the September 18 issue partly explains their negative findings. Previous studies by many groups¹ ² ³ have shown a definitive interaction between digoxin and quinidine, and the method used in most of these studies has been to increase doses until patients have steady-state digoxin levels, and then to introduce quinidine and study the effect. A similar study designed by Storstein et al.⁴ measured the changing clearance and serum elimination half-time in fully digitalized patients who were given quinidine. Peters et al.⁵ also studied fully digitalized patients, who.

Original language	English (US)
Pages (from-to)	118-119
Number of pages	2
Journal	New England Journal of Medicine
Volume	304
Issue number	2
DOIs	https://doi.org/10.1056/NEJM198101083040215
State	Published - Jan 8 1981

ASJC Scopus subject areas

General Medicine

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title = "Noninteraction of Digitoxin and Quinidine",

abstract = "To the Editor: The study design employed by Ochs et al. in their article in the September 18 issue partly explains their negative findings. Previous studies by many groups1 2 3 have shown a definitive interaction between digoxin and quinidine, and the method used in most of these studies has been to increase doses until patients have steady-state digoxin levels, and then to introduce quinidine and study the effect. A similar study designed by Storstein et al.4 measured the changing clearance and serum elimination half-time in fully digitalized patients who were given quinidine. Peters et al.5 also studied fully digitalized patients, who.",

author = "Melvin, {Kenneth R.} and Kates, {Robert E.} and Rollins, {Douglas E.} and Moshe Garty and Fenster, {Paul E.} and Marcus, {Frank I.} and Kenneth Conrad and Graves, {Penelope E.} and Hager, {W. David} and Powell, {J. Robert} and Ochs, {Hermann R.} and Greenblatt, {David J.}",

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doi = "10.1056/NEJM198101083040215",

language = "English (US)",

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T1 - Noninteraction of Digitoxin and Quinidine

AU - Melvin, Kenneth R.

AU - Kates, Robert E.

AU - Rollins, Douglas E.

AU - Garty, Moshe

AU - Fenster, Paul E.

AU - Marcus, Frank I.

AU - Conrad, Kenneth

AU - Graves, Penelope E.

AU - Hager, W. David

AU - Powell, J. Robert

AU - Ochs, Hermann R.

AU - Greenblatt, David J.

PY - 1981/1/8

Y1 - 1981/1/8

N2 - To the Editor: The study design employed by Ochs et al. in their article in the September 18 issue partly explains their negative findings. Previous studies by many groups1 2 3 have shown a definitive interaction between digoxin and quinidine, and the method used in most of these studies has been to increase doses until patients have steady-state digoxin levels, and then to introduce quinidine and study the effect. A similar study designed by Storstein et al.4 measured the changing clearance and serum elimination half-time in fully digitalized patients who were given quinidine. Peters et al.5 also studied fully digitalized patients, who.

AB - To the Editor: The study design employed by Ochs et al. in their article in the September 18 issue partly explains their negative findings. Previous studies by many groups1 2 3 have shown a definitive interaction between digoxin and quinidine, and the method used in most of these studies has been to increase doses until patients have steady-state digoxin levels, and then to introduce quinidine and study the effect. A similar study designed by Storstein et al.4 measured the changing clearance and serum elimination half-time in fully digitalized patients who were given quinidine. Peters et al.5 also studied fully digitalized patients, who.

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Noninteraction of Digitoxin and Quinidine

Abstract

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