Noncirrhotic portal fibrosis after Wilms' tumor therapy

John A. Barnard, Gary S. Marshall, Wallace W. Neblett, George Gray, Fayez K. Ghishan

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


A 9-yr-old girl developed massive hemorrhage from esophageal varices 2 yr after combined modality therapy for Wilms' tumor. Evaluation showed a patent extrahepatic portal venous system and an elevated splenic pulp pressure. In contrast to previous reports of hepatopathy after irradiation injury, histologic sections of the liver did not demonstrate occlusion of the central veins, but rather a diffuse obliteration of intrahepatic portal venous radicles. This pattern of noncirrhotic portal fibrosis has not been described following antitumor therapy.

Original languageEnglish (US)
Pages (from-to)1054-1056
Number of pages3
Issue number4
StatePublished - Apr 1986

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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