Noncirrhotic portal fibrosis after Wilms' tumor therapy

John A. Barnard; Gary S. Marshall; Wallace W. Neblett; George Gray; Fayez K. Ghishan

doi:10.1016/0016-5085(86)90888-7

Noncirrhotic portal fibrosis after Wilms' tumor therapy

John A. Barnard, Gary S. Marshall, Wallace W. Neblett, George Gray, Fayez K. Ghishan

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

A 9-yr-old girl developed massive hemorrhage from esophageal varices 2 yr after combined modality therapy for Wilms' tumor. Evaluation showed a patent extrahepatic portal venous system and an elevated splenic pulp pressure. In contrast to previous reports of hepatopathy after irradiation injury, histologic sections of the liver did not demonstrate occlusion of the central veins, but rather a diffuse obliteration of intrahepatic portal venous radicles. This pattern of noncirrhotic portal fibrosis has not been described following antitumor therapy.

Original language	English (US)
Pages (from-to)	1054-1056
Number of pages	3
Journal	Gastroenterology
Volume	90
Issue number	4
DOIs	https://doi.org/10.1016/0016-5085(86)90888-7
State	Published - Apr 1986
Externally published	Yes

ASJC Scopus subject areas

Hepatology
Gastroenterology

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title = "Noncirrhotic portal fibrosis after Wilms' tumor therapy",

abstract = "A 9-yr-old girl developed massive hemorrhage from esophageal varices 2 yr after combined modality therapy for Wilms' tumor. Evaluation showed a patent extrahepatic portal venous system and an elevated splenic pulp pressure. In contrast to previous reports of hepatopathy after irradiation injury, histologic sections of the liver did not demonstrate occlusion of the central veins, but rather a diffuse obliteration of intrahepatic portal venous radicles. This pattern of noncirrhotic portal fibrosis has not been described following antitumor therapy.",

author = "Barnard, {John A.} and Marshall, {Gary S.} and Neblett, {Wallace W.} and George Gray and Ghishan, {Fayez K.}",

year = "1986",

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AU - Barnard, John A.

AU - Marshall, Gary S.

AU - Neblett, Wallace W.

AU - Gray, George

AU - Ghishan, Fayez K.

PY - 1986/4

Y1 - 1986/4

N2 - A 9-yr-old girl developed massive hemorrhage from esophageal varices 2 yr after combined modality therapy for Wilms' tumor. Evaluation showed a patent extrahepatic portal venous system and an elevated splenic pulp pressure. In contrast to previous reports of hepatopathy after irradiation injury, histologic sections of the liver did not demonstrate occlusion of the central veins, but rather a diffuse obliteration of intrahepatic portal venous radicles. This pattern of noncirrhotic portal fibrosis has not been described following antitumor therapy.

AB - A 9-yr-old girl developed massive hemorrhage from esophageal varices 2 yr after combined modality therapy for Wilms' tumor. Evaluation showed a patent extrahepatic portal venous system and an elevated splenic pulp pressure. In contrast to previous reports of hepatopathy after irradiation injury, histologic sections of the liver did not demonstrate occlusion of the central veins, but rather a diffuse obliteration of intrahepatic portal venous radicles. This pattern of noncirrhotic portal fibrosis has not been described following antitumor therapy.

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JO - Gastroenterology

JF - Gastroenterology

IS - 4

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Noncirrhotic portal fibrosis after Wilms' tumor therapy

Abstract

ASJC Scopus subject areas

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