Nonalcoholic fatty liver disease: A comprehensive review of a growing epidemic

Kareem Hassan; Varun Bhalla; Mohammed Ezz El Regal; H. Hesham A-Kader

doi:10.3748/wjg.v20.i34.12082

Nonalcoholic fatty liver disease: A comprehensive review of a growing epidemic

Kareem Hassan, Varun Bhalla, Mohammed Ezz El Regal, H. Hesham A-Kader

Pediatrics

Research output: Contribution to journal › Review article › peer-review

151 Scopus citations

Abstract

Nonalcoholic fatty liver disease (NAFLD) is quickly becoming one of the most prominent causes of liver disease worldwide. The increasing incidence of NAFLD is tied to the obesity epidemic and the subsequent metabolic derangements brought along with it. Current efforts to elucidate the mechanism and causes of the disease have answered some questions, but much remains unknown about NAFLD. The aim of this article is to discuss the current knowledge regarding the pathogenesis of the disease, as well as the current and future diagnostic, preventative, and therapeutic options available to clinicians for the management of NAFLD.

Original language	English (US)
Pages (from-to)	12082-12101
Number of pages	20
Journal	World Journal of Gastroenterology
Volume	20
Issue number	34
DOIs	https://doi.org/10.3748/wjg.v20.i34.12082
State	Published - Sep 14 2014

Keywords

Diagnosis
Imaging
Management
Metformin
Nonalcoholic fatty liver disease
Nonalcoholic steatohepatitis
Pathogenesis
Prevalence
Steatohepatitis
Thiazolidinedione
Treatments
Vitamin E

ASJC Scopus subject areas

Gastroenterology

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10.3748/wjg.v20.i34.12082

Cite this

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title = "Nonalcoholic fatty liver disease: A comprehensive review of a growing epidemic",

abstract = "Nonalcoholic fatty liver disease (NAFLD) is quickly becoming one of the most prominent causes of liver disease worldwide. The increasing incidence of NAFLD is tied to the obesity epidemic and the subsequent metabolic derangements brought along with it. Current efforts to elucidate the mechanism and causes of the disease have answered some questions, but much remains unknown about NAFLD. The aim of this article is to discuss the current knowledge regarding the pathogenesis of the disease, as well as the current and future diagnostic, preventative, and therapeutic options available to clinicians for the management of NAFLD.",

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T2 - A comprehensive review of a growing epidemic

AU - Hassan, Kareem

AU - Bhalla, Varun

AU - El Regal, Mohammed Ezz

AU - Hesham A-Kader, H.

PY - 2014/9/14

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N2 - Nonalcoholic fatty liver disease (NAFLD) is quickly becoming one of the most prominent causes of liver disease worldwide. The increasing incidence of NAFLD is tied to the obesity epidemic and the subsequent metabolic derangements brought along with it. Current efforts to elucidate the mechanism and causes of the disease have answered some questions, but much remains unknown about NAFLD. The aim of this article is to discuss the current knowledge regarding the pathogenesis of the disease, as well as the current and future diagnostic, preventative, and therapeutic options available to clinicians for the management of NAFLD.

AB - Nonalcoholic fatty liver disease (NAFLD) is quickly becoming one of the most prominent causes of liver disease worldwide. The increasing incidence of NAFLD is tied to the obesity epidemic and the subsequent metabolic derangements brought along with it. Current efforts to elucidate the mechanism and causes of the disease have answered some questions, but much remains unknown about NAFLD. The aim of this article is to discuss the current knowledge regarding the pathogenesis of the disease, as well as the current and future diagnostic, preventative, and therapeutic options available to clinicians for the management of NAFLD.

KW - Diagnosis

KW - Imaging

KW - Management

KW - Metformin

KW - Nonalcoholic fatty liver disease

KW - Nonalcoholic steatohepatitis

KW - Pathogenesis

KW - Prevalence

KW - Steatohepatitis

KW - Thiazolidinedione

KW - Treatments

KW - Vitamin E

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Nonalcoholic fatty liver disease: A comprehensive review of a growing epidemic

Abstract

Keywords

ASJC Scopus subject areas

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