Nonalcoholic fatty liver disease: A comprehensive review of a growing epidemic

Kareem Hassan, Varun Bhalla, Mohammed Ezz El Regal, H. Hesham A-Kader

Research output: Contribution to journalReview articlepeer-review

130 Scopus citations


Nonalcoholic fatty liver disease (NAFLD) is quickly becoming one of the most prominent causes of liver disease worldwide. The increasing incidence of NAFLD is tied to the obesity epidemic and the subsequent metabolic derangements brought along with it. Current efforts to elucidate the mechanism and causes of the disease have answered some questions, but much remains unknown about NAFLD. The aim of this article is to discuss the current knowledge regarding the pathogenesis of the disease, as well as the current and future diagnostic, preventative, and therapeutic options available to clinicians for the management of NAFLD.

Original languageEnglish (US)
Pages (from-to)12082-12101
Number of pages20
JournalWorld Journal of Gastroenterology
Issue number34
StatePublished - Sep 14 2014


  • Diagnosis
  • Imaging
  • Management
  • Metformin
  • Nonalcoholic fatty liver disease
  • Nonalcoholic steatohepatitis
  • Pathogenesis
  • Prevalence
  • Steatohepatitis
  • Thiazolidinedione
  • Treatments
  • Vitamin E

ASJC Scopus subject areas

  • Gastroenterology


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