TY - JOUR
T1 - Non-Hodgkin's Lymphoma in 90 Homosexual Men
T2 - Relation to Generalized Lymphadenopathy and the Acquired Immunodeficiency Syndrome
AU - Ziegler, John L.
AU - Beckstead, Jay A.
AU - Volberding, Paul A.
AU - Abrams, Donald I.
AU - Levine, Alexandra M.
AU - Lukes, Robert J.
AU - Gill, Parkash S.
AU - Burkes, Ronald L.
AU - Meyer, Paul R.
AU - Metroka, Craig E.
AU - Mouradian, Janet
AU - Moore, Anne
AU - Riggs, Shirley A.
AU - Butler, James J.
AU - Cabanillas, Fernando C.
AU - Hersh, Evan
AU - Newell, Guy R.
AU - Laubenstein, Linda J.
AU - Knowles, Daniel
AU - Odajnyk, Chrystia
AU - Raphael, Bruce
AU - Koziner, Benjamin
AU - Urmacher, Carlos
AU - Glarkson, Bayard D.
PY - 1984/8/30
Y1 - 1984/8/30
N2 - We describe the histologic and clinical features of non-Hodgkin's lymphoma diagnosed between January 1980 and December 1983 in 90 homosexual men from San Francisco, Los Angeles, Houston, and New York. The median age was 37 years, with an age distribution identical to that for cases of AIDS reported to the Centers for Disease Control. Sixty-two per cent of the patients had high-grade (aggressive) subtypes of lymphoma, 29 per cent had subtypes of intermediate grade, and 7 per cent had low-grade subtypes. Histologic subtypes and malignant cell phenotypes were consistent with a B-cell origin. All but two men had extranodal lymphoma: Central-nervous-system, bone-marrow, bowel, and mucocutaneous sites were most commonly involved. Thirty-five of 66 evaluable men (53 per cent) had complete responses to combination chemotherapy or radiotherapy or both, and thus far, 19 (54 per cent) of them have had a relapse. Mortality and morbidity were closely related to prodromal manifestations; death or illness have occurred in 19 (91 per cent) of the 21 men who presented with AIDS, in 26 (79 per cent) of the 33 who presented with generalized lymphadenopathy, and in 5 (42 per cent) of the 12 who had no prodromal manifestations. Mortality rates analyzed according to histologic grade were higher than currently reported rates in other patient populations. Kaposi's sarcoma or severe opportunistic infections characteristic of AIDS developed in 14 of 33 men (42 per cent) who presented with generalized lymphadenopathy and in 3 of 12 (33 per cent) without prodromal manifestations. We conclude that non-Hodgkin's lymphoma in members of an AIDS risk group is a serious manifestation of AIDS and the AIDS-related complex. (N Engl J Med 1984; 311:565–70.).
AB - We describe the histologic and clinical features of non-Hodgkin's lymphoma diagnosed between January 1980 and December 1983 in 90 homosexual men from San Francisco, Los Angeles, Houston, and New York. The median age was 37 years, with an age distribution identical to that for cases of AIDS reported to the Centers for Disease Control. Sixty-two per cent of the patients had high-grade (aggressive) subtypes of lymphoma, 29 per cent had subtypes of intermediate grade, and 7 per cent had low-grade subtypes. Histologic subtypes and malignant cell phenotypes were consistent with a B-cell origin. All but two men had extranodal lymphoma: Central-nervous-system, bone-marrow, bowel, and mucocutaneous sites were most commonly involved. Thirty-five of 66 evaluable men (53 per cent) had complete responses to combination chemotherapy or radiotherapy or both, and thus far, 19 (54 per cent) of them have had a relapse. Mortality and morbidity were closely related to prodromal manifestations; death or illness have occurred in 19 (91 per cent) of the 21 men who presented with AIDS, in 26 (79 per cent) of the 33 who presented with generalized lymphadenopathy, and in 5 (42 per cent) of the 12 who had no prodromal manifestations. Mortality rates analyzed according to histologic grade were higher than currently reported rates in other patient populations. Kaposi's sarcoma or severe opportunistic infections characteristic of AIDS developed in 14 of 33 men (42 per cent) who presented with generalized lymphadenopathy and in 3 of 12 (33 per cent) without prodromal manifestations. We conclude that non-Hodgkin's lymphoma in members of an AIDS risk group is a serious manifestation of AIDS and the AIDS-related complex. (N Engl J Med 1984; 311:565–70.).
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U2 - 10.1056/NEJM198408303110904
DO - 10.1056/NEJM198408303110904
M3 - Article
C2 - 6611504
AN - SCOPUS:0021713481
SN - 0028-4793
VL - 311
SP - 565
EP - 570
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 9
ER -