NO problem for nitroglycerin: Organic nitrate chemistry and therapy

Gregory R.J. Thatcher, Hazel Weldon

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


Nitroglycerin (GTN) has been used clinically in the treatment of angina for over a century and is representative of the organic nitrates vasodilators. These are effective therapeutic agents that allow facile sublingual or transdermal administration. The vasodilatory mechanism involves activation of guanylate cyclase and is widely believed to involve biotransformation by chemical reaction of a nitrate with sulfhydryl or ferrous groups to yield nitric oxide. However, the chemistry of organic nitrates is poorly studied, provides scant support for these postulated reactions and provides a challenge for the chemist.

Original languageEnglish (US)
Pages (from-to)331-337
Number of pages7
JournalChemical Society Reviews
Issue number5
StatePublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)


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