No False Hemoccult Reaction with Ranitidine

Joseph M. Devito, David E. Nix, Jerome J. Schentag

Research output: Contribution to journalLetterpeer-review


To the Editor: The Hemoccult slide test (Smith Kline Diagnostics) is often used to test for occult blood in gastric aspirates. Results from this test have been shown to be falsely negative at low pHs found in gastric fluid1,2 or falsely positive as a result of oral cimetidine administration.3 Cimetidine's interference with the Hemoccult test is thought to be a consequence of the tablet dye used in formulation.4 Since ranitidine is often used in the same clinical situations, we investigated whether ranitidine or any constituents in the tablet formulation might also alter the results of the Hemoccult slide test. Gastric-aspirate.

Original languageEnglish (US)
Pages (from-to)861
Number of pages1
JournalNew England Journal of Medicine
Issue number13
StatePublished - Sep 27 1984

ASJC Scopus subject areas

  • General Medicine


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