No effect of sex steroids on compensatory muscle hypertrophy

S. R. Max, N. E. Rance

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


We studied the effects of sex steroids on muscle weight and oxidative capacity of rat plantaris muscles subjected to functional overload by removal of synergistic muscles. Eight weeks after bilateral synergist removal, plantaris muscles were strikingly hypertrophic compared with unoperated controls. After this period, there were selective alterations in the ability of the muscles to oxidize three substrates of oxidative metabolism. Thus 14CO2 production from [6-14C]glucose and [2-14C]pyruvate was significantly reduced, whereas there was no alteration in 14CO2 production from β-[3-14C]hydroxybutyrate. Succinate dehydrogenase specific activity was decreased in overloaded muscle. There was no effect of sex hormone status on any of these parameters. Finally, 30 days of functional overload did not influence cytosolic androgen receptor binding. These results are not consistent with the idea that sex steroids and functional overload act synergistically.

Original languageEnglish (US)
Pages (from-to)1589-1593
Number of pages5
JournalJournal of Applied Physiology Respiratory Environmental and Exercise Physiology
Issue number6
StatePublished - 1984

ASJC Scopus subject areas

  • Physiology
  • Endocrinology


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