No association of dysbindin with symptom factors of schizophrenia in an Irish case-control sample

Sarah E. Bergen, Ayman H. Fanous, Po Hsiu Kuo, Brandon K. Wormley, F. Anthony O'Neill, Dermot Walsh, Brien P. Riley, Kenneth S. Kendler

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Robust associations between the dysbindin gene (DTNBP1) and schizophrenia have been demonstrated in many but not all samples, and evidence that this gene particularly predisposes to negative symptoms in this illness has been presented. The current study sought to replicate the previously reported negative symptom associations in an Irish case-control sample. Association between dysbindin and schizophrenia has been established in this cohort, and a factor analysis of the assessed symptoms yielded three factors, Positive, Negative, and Schneiderian. The sequential addition method was applied using UNPHASED to assess the relationship between these symptom factors and the high-risk haplotype. No associations were detected for any of the symptom factors indicating that the dysbindin risk haplotype does not predispose to a particular group of symptoms in this sample. Several possibilities, such as differing risk haplotypes, may explain this finding.

Original languageEnglish (US)
Pages (from-to)700-705
Number of pages6
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume153
Issue number2
DOIs
StatePublished - Mar 2010
Externally publishedYes

Keywords

  • Modifier
  • Negative symptoms
  • Sequential addition

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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