TY - JOUR
T1 - Nitroxyl (HNO)
T2 - Chemistry, biochemistry, and pharmacology
AU - Fukuto, Jon M.
AU - Switzer, Christopher H.
AU - Miranda, Katrina M.
AU - Wink, David A.
PY - 2005
Y1 - 2005
N2 - Recent discoveries of novel and potentially important biological activity have spurred interest in the chemistry and biochemistry of nitroxyl (HNO). It has become clear that, among all the nitrogen oxides, HNO is unique in its chemistry and biology. Currently, the intimate chemical details of the biological actions of HNO are not well understood. Moreover, many of the previously accepted chemical properties of HNO have been recently revised, thus requiring reevaluation of possible mechanisms of biological action. Herein, we review these developments in HNO chemistry and biology.
AB - Recent discoveries of novel and potentially important biological activity have spurred interest in the chemistry and biochemistry of nitroxyl (HNO). It has become clear that, among all the nitrogen oxides, HNO is unique in its chemistry and biology. Currently, the intimate chemical details of the biological actions of HNO are not well understood. Moreover, many of the previously accepted chemical properties of HNO have been recently revised, thus requiring reevaluation of possible mechanisms of biological action. Herein, we review these developments in HNO chemistry and biology.
KW - Calcitonin gene-related peptide
KW - Ischemia-reperfusion
KW - Nitric oxide
KW - Thiols
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U2 - 10.1146/annurev.pharmtox.45.120403.095959
DO - 10.1146/annurev.pharmtox.45.120403.095959
M3 - Review article
C2 - 15822180
AN - SCOPUS:13844322060
SN - 0362-1642
VL - 45
SP - 335
EP - 355
JO - Annual review of pharmacology and toxicology
JF - Annual review of pharmacology and toxicology
ER -