Nitrate esters as nitric oxide donors: SS-nitrates

Sergei I. Zavorin, Jennifer D. Artz, Adina Dumitrascu, Adrian Nicolescu, Dan Scutaru, Stefanie V. Smith, Gregory R.J. Thatcher

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Matrix presented The important biological secondary messenger NO can be generated from exogenous nitrovasodilators and NO donors. Nitrate esters are nitrovasodilators and NO mimetics, believed to be biotransformed to NO in vivo. On the basis of a mechanistic hypothesis, nitrates have been synthesized that release NO at significant rates in neutral aqueous solution in the presence only of added thiol. The novel masked β-mercaptonitrates reported (SS-nitrates), provide information on possible sulfhydryl-dependent biotransformation mechanisms for nitrates in clinical use.

Original languageEnglish (US)
Pages (from-to)1113-1116
Number of pages4
JournalOrganic Letters
Issue number8
StatePublished - Apr 19 2001
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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