Nicardipine notes: Fatal forty DDI: Nicardipine, tacrolimus, CYP3A4

Nenna Nwazota; Randal O. Dull

doi:10.1007/978-1-4614-7495-1_125

Nicardipine notes: Fatal forty DDI: Nicardipine, tacrolimus, CYP3A4

Nenna Nwazota
, Randal O. Dull

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

This case discusses an interaction between tacrolimus and nicardipine. Tacrolimus is a cytochrome P450 3A4 substrate and nicardipine is a 3A4 inhibitor. The interaction resulted in tacrolimus toxicity. The pharmacokinetics of nicardipine are also discussed.

Original language	English (US)
Title of host publication	A Case Approach to Perioperative Drug-Drug Interactions
Publisher	Springer New York
Pages	569-571
Number of pages	3
ISBN (Electronic)	9781461474951
ISBN (Print)	9781461474944
DOIs	https://doi.org/10.1007/978-1-4614-7495-1_125
State	Published - Sep 15 2015
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1007/978-1-4614-7495-1_125

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AB - This case discusses an interaction between tacrolimus and nicardipine. Tacrolimus is a cytochrome P450 3A4 substrate and nicardipine is a 3A4 inhibitor. The interaction resulted in tacrolimus toxicity. The pharmacokinetics of nicardipine are also discussed.

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Nicardipine notes: Fatal forty DDI: Nicardipine, tacrolimus, CYP3A4

Abstract

ASJC Scopus subject areas

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