Nicardipine notes: Fatal forty DDI: Nicardipine, tacrolimus, CYP3A4

Nenna Nwazota, Randal O. Dull

Research output: Chapter in Book/Report/Conference proceedingChapter


This case discusses an interaction between tacrolimus and nicardipine. Tacrolimus is a cytochrome P450 3A4 substrate and nicardipine is a 3A4 inhibitor. The interaction resulted in tacrolimus toxicity. The pharmacokinetics of nicardipine are also discussed.

Original languageEnglish (US)
Title of host publicationA Case Approach to Perioperative Drug-Drug Interactions
PublisherSpringer New York
Number of pages3
ISBN (Electronic)9781461474951
ISBN (Print)9781461474944
StatePublished - Sep 15 2015

ASJC Scopus subject areas

  • General Medicine


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