Newborn piglet model for campylobacteriosis

F. K. Babakhani, G. A. Bradley, L. A. Joens

Research output: Contribution to journalArticlepeer-review

73 Scopus citations


An in vivo model system for human campylobacteriosis has been developed in which colostrum-deprived newborn piglets are orally challenged with an invasive strain of Campylobacter jejuni. Piglets developed clinical symptoms and histopathological lesions similar to those observed in humans infected with C. jejuni. Gross lesion examination at autopsy revealed the presence of edema, hyperemia, and mucus. Histopathologic examinations by light and transmission electron microscopy demonstrated damage to surface epithelial cells with the presence of intracellular bacteria, mainly in the large intestine. Similar lesions were not demonstrated in control piglets.

Original languageEnglish (US)
Pages (from-to)3466-3475
Number of pages10
JournalInfection and Immunity
Issue number8
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases


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