New insights into the pathogenesis of cystic fibrosis sinusitis

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Background: People with cystic fibrosis (CF) sinus disease have developmental sinus abnormalities with airway bacterial infection, inflammation, impaired mucociliary clearance and thick obstructive mucus. The pathophysiology of airway disease in CF is not completely understood, and current treatments in CF sinus disease ameliorate symptoms but do not provide a cure. Methods: This manuscript reviews the history of CF, its manifestations in sinus disease, and the potential impact and relationship of CF on the upper and lower airway. Results: There is increasing evidence that CF sinus disease may affect CF lung disease, the most common cause of mortality in CF. We have been limited in treating the symptoms of advanced CF sinus disease with our current therapies. Conclusions: Recent discoveries in the pathophysiology of CF using the CF porcine animal model and exciting treatments that address the primary gene defect that may translate into improved outcomes in CF and non-CF sinusitis in humans.

Original languageEnglish (US)
Pages (from-to)132-137
Number of pages6
JournalInternational Forum of Allergy and Rhinology
Issue number2
StatePublished - Feb 2014
Externally publishedYes


  • Airway biology
  • CFTR
  • Electrophysiology
  • Gene therapy
  • Ion transport

ASJC Scopus subject areas

  • Immunology and Allergy
  • Otorhinolaryngology


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