TY - JOUR
T1 - New insights into the molecular basis of glucocorticoid action
AU - Bloom, J. W.
PY - 1999
Y1 - 1999
N2 - Understanding the molecular mechanisms of glucocorticoid action is a primary step in the development of more effective therapeutic agents. An important part of the anti-inflammatory effects of glucocorticoids in asthma involves repression of the expression of inflammatory mediators, particularly cytokines. The NFκB and AP-1 transcription factors seem to be involved in the expression of a number of crucial target genes in asthma, and there are several possible mechanisms through which glucocorticoids may repress genes regulated by NFκB and AP-1. Recent studies also have demonstrated a significant role for steroid-nuclear receptor coactivators, histone acetylation, and chromatin structure in gene regulation. These newly described mechanisms of gene regulation are discussed in relation to the molecular basis of glucocorticoid action.
AB - Understanding the molecular mechanisms of glucocorticoid action is a primary step in the development of more effective therapeutic agents. An important part of the anti-inflammatory effects of glucocorticoids in asthma involves repression of the expression of inflammatory mediators, particularly cytokines. The NFκB and AP-1 transcription factors seem to be involved in the expression of a number of crucial target genes in asthma, and there are several possible mechanisms through which glucocorticoids may repress genes regulated by NFκB and AP-1. Recent studies also have demonstrated a significant role for steroid-nuclear receptor coactivators, histone acetylation, and chromatin structure in gene regulation. These newly described mechanisms of gene regulation are discussed in relation to the molecular basis of glucocorticoid action.
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U2 - 10.1016/S0889-8561(05)70115-6
DO - 10.1016/S0889-8561(05)70115-6
M3 - Article
AN - SCOPUS:0032711769
SN - 0889-8561
VL - 19
SP - 653
EP - 670
JO - Immunology and Allergy Clinics of North America
JF - Immunology and Allergy Clinics of North America
IS - 4
ER -