New hirsutane based sesquiterpenes from salt water cultures of a marine sponge-derived fungus and the terrestrial fungus Coriolus consors

Gui Yang Sheng Wang; Leif M. Abrell; Abigail Avelar; Bethel M. Borgeson; Phillip Crews

doi:10.1016/S0040-4020(98)00398-6

New hirsutane based sesquiterpenes from salt water cultures of a marine sponge-derived fungus and the terrestrial fungus Coriolus consors

Gui Yang Sheng Wang, Leif M. Abrell, Abigail Avelar, Bethel M. Borgeson, Phillip Crews

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

Five new cyclic sesquiterpenes, hirsutanols A (6), B (7), C (8), hirsutanol D (9), and ent-gloeosteretriol (10) and a new diketopiperazine (14) were isolated from salt water cultures of two fungi. Seaquiterpenes 6 - 8 and 10 were obtained from an unidentified fungus separated from an Indo- Pacific sponge Haliclona sp. while 9 and 14 were produced by the terrestrial fungus Coriolus consors cultured under both sea water and deionized water media. Hirsutanol A (6) and ent-gloeosteretriol (10) were found to be anti- microbial (Bacillus subtilus) active. All structures were elucidated by spectroscopic methods.

Original language	English (US)
Pages (from-to)	7335-7342
Number of pages	8
Journal	Tetrahedron
Volume	54
Issue number	26
DOIs	https://doi.org/10.1016/S0040-4020(98)00398-6
State	Published - Jun 25 1998
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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title = "New hirsutane based sesquiterpenes from salt water cultures of a marine sponge-derived fungus and the terrestrial fungus Coriolus consors",

abstract = "Five new cyclic sesquiterpenes, hirsutanols A (6), B (7), C (8), hirsutanol D (9), and ent-gloeosteretriol (10) and a new diketopiperazine (14) were isolated from salt water cultures of two fungi. Seaquiterpenes 6 - 8 and 10 were obtained from an unidentified fungus separated from an Indo- Pacific sponge Haliclona sp. while 9 and 14 were produced by the terrestrial fungus Coriolus consors cultured under both sea water and deionized water media. Hirsutanol A (6) and ent-gloeosteretriol (10) were found to be anti- microbial (Bacillus subtilus) active. All structures were elucidated by spectroscopic methods.",

author = "Wang, {Gui Yang Sheng} and Abrell, {Leif M.} and Abigail Avelar and Borgeson, {Bethel M.} and Phillip Crews",

note = "Funding Information: Acknowledgments: Support for these studies was provided by NOAA California Sea Grant R-MP/63 and NIH U19 grant CA52955. NMR equipment grants were from NSF BIR-94-19409 and the Elsa U. Pardee Foundation, and an ESIMS equipment grant from the Keck Foundation. L.M.A. was partially supported by the UC Biotechnology Training Program SC/95-38; A.A. was supported by an MBRS program grant GM08132 and a Howard Hughes summer Fellowship.",

year = "1998",

month = jun,

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doi = "10.1016/S0040-4020(98)00398-6",

language = "English (US)",

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T1 - New hirsutane based sesquiterpenes from salt water cultures of a marine sponge-derived fungus and the terrestrial fungus Coriolus consors

AU - Wang, Gui Yang Sheng

AU - Abrell, Leif M.

AU - Avelar, Abigail

AU - Borgeson, Bethel M.

AU - Crews, Phillip

N1 - Funding Information: Acknowledgments: Support for these studies was provided by NOAA California Sea Grant R-MP/63 and NIH U19 grant CA52955. NMR equipment grants were from NSF BIR-94-19409 and the Elsa U. Pardee Foundation, and an ESIMS equipment grant from the Keck Foundation. L.M.A. was partially supported by the UC Biotechnology Training Program SC/95-38; A.A. was supported by an MBRS program grant GM08132 and a Howard Hughes summer Fellowship.

PY - 1998/6/25

Y1 - 1998/6/25

N2 - Five new cyclic sesquiterpenes, hirsutanols A (6), B (7), C (8), hirsutanol D (9), and ent-gloeosteretriol (10) and a new diketopiperazine (14) were isolated from salt water cultures of two fungi. Seaquiterpenes 6 - 8 and 10 were obtained from an unidentified fungus separated from an Indo- Pacific sponge Haliclona sp. while 9 and 14 were produced by the terrestrial fungus Coriolus consors cultured under both sea water and deionized water media. Hirsutanol A (6) and ent-gloeosteretriol (10) were found to be anti- microbial (Bacillus subtilus) active. All structures were elucidated by spectroscopic methods.

AB - Five new cyclic sesquiterpenes, hirsutanols A (6), B (7), C (8), hirsutanol D (9), and ent-gloeosteretriol (10) and a new diketopiperazine (14) were isolated from salt water cultures of two fungi. Seaquiterpenes 6 - 8 and 10 were obtained from an unidentified fungus separated from an Indo- Pacific sponge Haliclona sp. while 9 and 14 were produced by the terrestrial fungus Coriolus consors cultured under both sea water and deionized water media. Hirsutanol A (6) and ent-gloeosteretriol (10) were found to be anti- microbial (Bacillus subtilus) active. All structures were elucidated by spectroscopic methods.

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JO - Tetrahedron

JF - Tetrahedron

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ER -

New hirsutane based sesquiterpenes from salt water cultures of a marine sponge-derived fungus and the terrestrial fungus Coriolus consors

Abstract

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