TY - JOUR
T1 - New approaches for the treatment of pain
T2 - The GDNF family of neurotrophic growth factors
AU - Sah, Dinah W.Y.
AU - Ossipov, Michael H.
AU - Rossomando, Anthony
AU - Silvian, Laura
AU - Porreca, Frank
PY - 2005
Y1 - 2005
N2 - This article focuses on the GDNF family of neurotrophic factors as a potential new class of therapeutics for neuropathic pain, with a particular emphasis on the ligands, artemin and GDNF. In vivo activity of the ligands, expression of ligands and receptors after peripheral nerve injury, and modulation of nerve injury-induced changes by the ligands are reviewed in detail. Structural considerations, particularly with regard to implications for binding interactions and biological activity are discussed.
AB - This article focuses on the GDNF family of neurotrophic factors as a potential new class of therapeutics for neuropathic pain, with a particular emphasis on the ligands, artemin and GDNF. In vivo activity of the ligands, expression of ligands and receptors after peripheral nerve injury, and modulation of nerve injury-induced changes by the ligands are reviewed in detail. Structural considerations, particularly with regard to implications for binding interactions and biological activity are discussed.
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U2 - 10.2174/1568026054367593
DO - 10.2174/1568026054367593
M3 - Review article
C2 - 16022680
AN - SCOPUS:22944465758
SN - 1568-0266
VL - 5
SP - 577
EP - 583
JO - Current topics in medicinal chemistry
JF - Current topics in medicinal chemistry
IS - 6
ER -