TY - JOUR
T1 - New advances in CMV and immunosenescence
AU - Sansoni, Paolo
AU - Vescovini, Rosanna
AU - Fagnoni, Francesco F.
AU - Akbar, Arne
AU - Arens, Ramon
AU - Chiu, Yen Ling
AU - Čičin-Šain, Luka
AU - Dechanet-Merville, Julie
AU - Derhovanessian, Evelyna
AU - Ferrando-Martinez, Sara
AU - Franceschi, Claudio
AU - Frasca, Daniela
AU - Fulöp, Tamas
AU - Furman, David
AU - Gkrania-Klotsas, Effrossyni
AU - Goodrum, Felicia
AU - Grubeck-Loebenstein, Beatrix
AU - Hurme, Mikko
AU - Kern, Florian
AU - Lilleri, Daniele
AU - López-Botet, Miguel
AU - Maier, Andrea B.
AU - Marandu, Thomas
AU - Marchant, Arnaud
AU - Matheï, Catharina
AU - Moss, Paul
AU - Muntasell, Aura
AU - Remmerswaal, Ester B.M.
AU - Riddell, Natalie E.
AU - Rothe, Kathrin
AU - Sauce, Delphine
AU - Shin, Eui Cheol
AU - Simanek, Amanda M.
AU - Smithey, Megan J.
AU - Söderberg-Nauclér, Cecilia
AU - Solana, Rafael
AU - Thomas, Paul G.
AU - Van Lier, Rene
AU - Pawelec, Graham
AU - Nikolich-Zugich, Janko
N1 - Funding Information:
The Workshop was partially supported by the University of Parma , Fondazione CARIPARMA and Regione Emilia-Romagna (Programma di Ricerca Regione/Università-AREA1. Strategic programme: “A TAILORED APPROACH TO THE IMMUNE-MONITORING AND CLINICAL MANAGEMENT OF VIRAL AND AUTOIMMUNE DIESEASE”) .
PY - 2014/7
Y1 - 2014/7
N2 - Immunosenescence, defined as the age-associated dysregulation and dysfunction of the immune system, is characterized by impaired protective immunity and decreased efficacy of vaccines. An increasing number of immunological, clinical and epidemiological studies suggest that persistent Cytomegalovirus (CMV) infection is associated with accelerated aging of the immune system and with several age-related diseases. However, current evidence on whether and how human CMV (HCMV) infection is implicated in immunosenescence and in age-related diseases remains incomplete and many aspects of CMV involvement in immune aging remain controversial. The attendees of the 4th International Workshop on "CMV & Immunosenescence", held in Parma, Italy, 25-27th March, 2013, presented and discussed data related to these open questions, which are reported in this commentary.
AB - Immunosenescence, defined as the age-associated dysregulation and dysfunction of the immune system, is characterized by impaired protective immunity and decreased efficacy of vaccines. An increasing number of immunological, clinical and epidemiological studies suggest that persistent Cytomegalovirus (CMV) infection is associated with accelerated aging of the immune system and with several age-related diseases. However, current evidence on whether and how human CMV (HCMV) infection is implicated in immunosenescence and in age-related diseases remains incomplete and many aspects of CMV involvement in immune aging remain controversial. The attendees of the 4th International Workshop on "CMV & Immunosenescence", held in Parma, Italy, 25-27th March, 2013, presented and discussed data related to these open questions, which are reported in this commentary.
KW - Cytomegalovirus infection
KW - Immune homeostasis
KW - Immunosenescence
KW - Pathologies of aging
KW - Virus-host interaction
UR - http://www.scopus.com/inward/record.url?scp=84898883473&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84898883473&partnerID=8YFLogxK
U2 - 10.1016/j.exger.2014.03.020
DO - 10.1016/j.exger.2014.03.020
M3 - Article
C2 - 24703889
AN - SCOPUS:84898883473
SN - 0531-5565
VL - 55
SP - 54
EP - 62
JO - Experimental Gerontology
JF - Experimental Gerontology
ER -