Neurotensin stimulates inositol phospholipid hydrolysis in rat brain slices

M. Goedert; R. D. Pinnock; C. P. Downes; P. W. Mantyh; P. C. Emson

doi:10.1016/0006-8993(84)90288-9

Neurotensin stimulates inositol phospholipid hydrolysis in rat brain slices

M. Goedert, R. D. Pinnock, C. P. Downes, P. W. Mantyh, P. C. Emson

Pharmacology

Research output: Contribution to journal › Article › peer-review

102 Scopus citations

Abstract

Neurotensin stimulated inositol phosphilipid hydrolysis in matched coronal vibratome sections through the rat brain. This effect was tetrodotoxin-resistant and a good correlation was noticed between the magnitude of neurotensin-stimulated inositol phospholipid hydrolysis and the number of specific [³H]neurotensin binding sites in various brain regions. Neurotensin produced no significant effect on either basal or stimulated cAMP levels.

Original language	English (US)
Pages (from-to)	193-197
Number of pages	5
Journal	Brain Research
Volume	323
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(84)90288-9
State	Published - Dec 3 1984

Keywords

cAMP
inositol phospholipid hydrolysis
neurotensin
second messengers

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(84)90288-9

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AU - Goedert, M.

AU - Pinnock, R. D.

AU - Downes, C. P.

AU - Mantyh, P. W.

AU - Emson, P. C.

PY - 1984/12/3

Y1 - 1984/12/3

N2 - Neurotensin stimulated inositol phosphilipid hydrolysis in matched coronal vibratome sections through the rat brain. This effect was tetrodotoxin-resistant and a good correlation was noticed between the magnitude of neurotensin-stimulated inositol phospholipid hydrolysis and the number of specific [3H]neurotensin binding sites in various brain regions. Neurotensin produced no significant effect on either basal or stimulated cAMP levels.

AB - Neurotensin stimulated inositol phosphilipid hydrolysis in matched coronal vibratome sections through the rat brain. This effect was tetrodotoxin-resistant and a good correlation was noticed between the magnitude of neurotensin-stimulated inositol phospholipid hydrolysis and the number of specific [3H]neurotensin binding sites in various brain regions. Neurotensin produced no significant effect on either basal or stimulated cAMP levels.

KW - cAMP

KW - inositol phospholipid hydrolysis

KW - neurotensin

KW - second messengers

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Neurotensin stimulates inositol phospholipid hydrolysis in rat brain slices

Abstract

Keywords

ASJC Scopus subject areas

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