TY - JOUR
T1 - Neuropsychologic function in toddlers exposed to cocaine in utero
T2 - A preliminary study
AU - Espy, Kimberly Andrews
AU - Kaufmann, Paul M.
AU - Glisky, Martha L.
N1 - Funding Information:
This research was supported, in part, by grants from the Center for Substance Abuse Prevention (H86 SP01638), from the University of Arizona (I/5ESPY), and from the office of Research Development and Administration, Southern Illinois University (SRA-19). We thank the staff at CODAC Behavioral Health Center, LaFrontera Center, and The Beginning School for assistance in participant recruitment and the parents of all children who participated. We recognize posthumously the contribu- tion of Catherine J. Locke, the original Director and Principal Investigator of Project CAMI. The comments of Marilyn Welsh and two anonymous reviewers are appreciated.
PY - 1999
Y1 - 1999
N2 - Patterns of neuropsychological performance on A-not-B, inhibition, motor, cognitive, language, and behavior tasks were examined in 34 toddlers- 17 cocaine-exposed (CE) and 17 nonexposed (NE) controls. CE toddlers exhibited greater perseveration, less inhibition, poorer emotional regulation, and less task orientation relative to NE toddlers. Overall cognitive and language skills and motor impairment status were comparable among CE and NE toddlers. Differences in perseveration, emotional regulation, and task orientation between CE and NE toddlers remained significant after statistically controlling for overall cognitive skill. Prenatal cocaine exposure may impart selective vulnerability for deficits in executive function, inhibition, and emotional regulation in toddlers, perhaps related to the concurrent rapid frontal lobe maturation and the neurobiology of cocaine. Furthermore, these findings suggest that performance can be broken down into meaningful neuropsychological components in very young children.
AB - Patterns of neuropsychological performance on A-not-B, inhibition, motor, cognitive, language, and behavior tasks were examined in 34 toddlers- 17 cocaine-exposed (CE) and 17 nonexposed (NE) controls. CE toddlers exhibited greater perseveration, less inhibition, poorer emotional regulation, and less task orientation relative to NE toddlers. Overall cognitive and language skills and motor impairment status were comparable among CE and NE toddlers. Differences in perseveration, emotional regulation, and task orientation between CE and NE toddlers remained significant after statistically controlling for overall cognitive skill. Prenatal cocaine exposure may impart selective vulnerability for deficits in executive function, inhibition, and emotional regulation in toddlers, perhaps related to the concurrent rapid frontal lobe maturation and the neurobiology of cocaine. Furthermore, these findings suggest that performance can be broken down into meaningful neuropsychological components in very young children.
UR - http://www.scopus.com/inward/record.url?scp=0032933711&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032933711&partnerID=8YFLogxK
U2 - 10.1080/87565649909540761
DO - 10.1080/87565649909540761
M3 - Article
AN - SCOPUS:0032933711
SN - 8756-5641
VL - 15
SP - 447
EP - 460
JO - Developmental Neuropsychology
JF - Developmental Neuropsychology
IS - 3
ER -