Neuroprotection against ischemic brain injury conferred by a novel nitrate ester

James N. Reynolds; Brian M. Bennett; Roland J. Boegman; Khem Jhamandas; Jodan D. Ratz; Sergei I. Zavorin; Dan Scutaru; Adina Dumitrascu; Gregory R.J. Thatcher

doi:10.1016/S0960-894X(02)00631-5

Neuroprotection against ischemic brain injury conferred by a novel nitrate ester

James N. Reynolds
, Brian M. Bennett
, Roland J. Boegman
, Khem Jhamandas
, Jodan D. Ratz
, Sergei I. Zavorin
, Dan Scutaru
, Adina Dumitrascu
, Gregory R.J. Thatcher

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Nitrates exhibit a selectivity of action in different tissue types not fully recognized: in particular, the neuromodulatory and cardiovascular properties can be dissociated. A novel nitrate showed relatively weak systemic effects, but in the middle cerebral artery occlusion rat model of focal ischemia, reduced the cerebral infarct by 60-70% when administered 4 h after the onset of ischemia.

Original language	English (US)
Pages (from-to)	2863-2866
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	12
Issue number	20
DOIs	https://doi.org/10.1016/S0960-894X(02)00631-5
State	Published - Oct 21 2002
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(02)00631-5

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title = "Neuroprotection against ischemic brain injury conferred by a novel nitrate ester",

abstract = "Nitrates exhibit a selectivity of action in different tissue types not fully recognized: in particular, the neuromodulatory and cardiovascular properties can be dissociated. A novel nitrate showed relatively weak systemic effects, but in the middle cerebral artery occlusion rat model of focal ischemia, reduced the cerebral infarct by 60-70\% when administered 4 h after the onset of ischemia.",

author = "Reynolds, \{James N.\} and Bennett, \{Brian M.\} and Boegman, \{Roland J.\} and Khem Jhamandas and Ratz, \{Jodan D.\} and Zavorin, \{Sergei I.\} and Dan Scutaru and Adina Dumitrascu and Thatcher, \{Gregory R.J.\}",

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T1 - Neuroprotection against ischemic brain injury conferred by a novel nitrate ester

AU - Reynolds, James N.

AU - Bennett, Brian M.

AU - Boegman, Roland J.

AU - Jhamandas, Khem

AU - Ratz, Jodan D.

AU - Zavorin, Sergei I.

AU - Scutaru, Dan

AU - Dumitrascu, Adina

AU - Thatcher, Gregory R.J.

PY - 2002/10/21

Y1 - 2002/10/21

N2 - Nitrates exhibit a selectivity of action in different tissue types not fully recognized: in particular, the neuromodulatory and cardiovascular properties can be dissociated. A novel nitrate showed relatively weak systemic effects, but in the middle cerebral artery occlusion rat model of focal ischemia, reduced the cerebral infarct by 60-70% when administered 4 h after the onset of ischemia.

AB - Nitrates exhibit a selectivity of action in different tissue types not fully recognized: in particular, the neuromodulatory and cardiovascular properties can be dissociated. A novel nitrate showed relatively weak systemic effects, but in the middle cerebral artery occlusion rat model of focal ischemia, reduced the cerebral infarct by 60-70% when administered 4 h after the onset of ischemia.

UR - https://www.scopus.com/pages/publications/0037152463

UR - https://www.scopus.com/pages/publications/0037152463#tab=citedBy

U2 - 10.1016/S0960-894X(02)00631-5

DO - 10.1016/S0960-894X(02)00631-5

M3 - Article

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AN - SCOPUS:0037152463

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 20

ER -

Neuroprotection against ischemic brain injury conferred by a novel nitrate ester

Abstract

ASJC Scopus subject areas

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