Neuroprotection against ischemic brain injury conferred by a novel nitrate ester

James N. Reynolds, Brian M. Bennett, Roland J. Boegman, Khem Jhamandas, Jodan D. Ratz, Sergei I. Zavorin, Dan Scutaru, Adina Dumitrascu, Gregory R.J. Thatcher

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Nitrates exhibit a selectivity of action in different tissue types not fully recognized: in particular, the neuromodulatory and cardiovascular properties can be dissociated. A novel nitrate showed relatively weak systemic effects, but in the middle cerebral artery occlusion rat model of focal ischemia, reduced the cerebral infarct by 60-70% when administered 4 h after the onset of ischemia.

Original languageEnglish (US)
Pages (from-to)2863-2866
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number20
StatePublished - Oct 21 2002
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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