Abstract
Substance P belongs to a group of neuropeptides known as the neurokinins (NKs). The biological effects of substance P in the central nervous system are mediated primarily by its binding to the NK-1 receptor. The NK-1 receptor is distributed in the plasma membrane of unstimulated cells and upon stimulation undergoes rapid internalization, followed by rapid recycling to the plasma membrane. Studies examining internalization of this neuropeptide-receptor complex have provided insights into when neuropeptides are activated in health and disease and have allowed the selective delivery of high-molecular weight therapies to the intracellular compartment of neuropeptide receptor-expressing cells.
Original language | English (US) |
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Title of host publication | Encyclopedia of Neuroscience |
Publisher | Elsevier Ltd. |
Pages | 867-871 |
Number of pages | 5 |
ISBN (Print) | 9780080450469 |
DOIs | |
State | Published - 2009 |
Keywords
- Affective behaviors
- Depression
- Endocytosis
- Pain
- Spinal cord
- Substance P
ASJC Scopus subject areas
- General Neuroscience