Neuropathic pain: the paradox of dynorphin.

J. Lai, M. H. Ossipov, T. W. Vanderah, T. P. Malan, F. Porreca

Research output: Contribution to journalReview articlepeer-review

69 Scopus citations


One of the curious but common consequences of opioid administration in the clinical setting is the induction, at sites uninvolved in the original presentation of discomfort, of pain itself. The induction of pain is also a reliable, measurable phenomenon in animals receiving continuous delivery of opioid. Such pain induction is associated with the expression of spinal dynorphin, a finding that is especially intriguing in light of dynorphin's ability to recapitulate many of the characteristics of chronic, neuropathic pain when administered intrathecally (i.e., into the spine). The effective treatment of chronic pain syndromes-and of tolerance to antinociceptive therapies-may thus rest on an understanding of the biological roles of dynorphin in neurotransmission.

Original languageEnglish (US)
Pages (from-to)160-167
Number of pages8
JournalMolecular interventions
Issue number3
StatePublished - Aug 2001

ASJC Scopus subject areas

  • Molecular Medicine


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