Neuronal regulation of pre-mRNA splicing by polypyrimidine tract binding proteins, PTBP1 and PTBP2

Niroshika Keppetipola; Shalini Sharma; Qin Li; Douglas L. Black

doi:10.3109/10409238.2012.691456

Neuronal regulation of pre-mRNA splicing by polypyrimidine tract binding proteins, PTBP1 and PTBP2

Niroshika Keppetipola
, Shalini Sharma
, Qin Li
, Douglas L. Black

Research output: Contribution to journal › Review article › peer-review

154 Scopus citations

Abstract

Alternative splicing patterns are regulated by RNA binding proteins that assemble onto each pre-mRNA to form a complex RNP structure. The polypyrimidine tract binding protein, PTB, has served as an informative model for understanding how RNA binding proteins affect spliceosome assembly and how changes in the expression of these proteins can control complex programs of splicing in tissues. In this review, we describe the mechanisms of splicing regulation by PTB and its function, along with its paralog PTBP2, in neuronal development.

Original language	English (US)
Pages (from-to)	360-378
Number of pages	19
Journal	Critical reviews in biochemistry and molecular biology
Volume	47
Issue number	4
DOIs	https://doi.org/10.3109/10409238.2012.691456
State	Published - Jul 2012
Externally published	Yes

Keywords

Alternative splicing
Neuronal development
RNA binding protein
RNP
Spliceosome

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.3109/10409238.2012.691456

Cite this

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title = "Neuronal regulation of pre-mRNA splicing by polypyrimidine tract binding proteins, PTBP1 and PTBP2",

abstract = "Alternative splicing patterns are regulated by RNA binding proteins that assemble onto each pre-mRNA to form a complex RNP structure. The polypyrimidine tract binding protein, PTB, has served as an informative model for understanding how RNA binding proteins affect spliceosome assembly and how changes in the expression of these proteins can control complex programs of splicing in tissues. In this review, we describe the mechanisms of splicing regulation by PTB and its function, along with its paralog PTBP2, in neuronal development.",

keywords = "Alternative splicing, Neuronal development, RNA binding protein, RNP, Spliceosome",

author = "Niroshika Keppetipola and Shalini Sharma and Qin Li and Black, \{Douglas L.\}",

note = "Funding Information: Our own work has been supported by NIH Grants RO1 GM49662, R24 GM070857 (to D.L.B.), fellowship and training grant support from an NRSA and 5T32 NS07449 (to N.K.) and from NARSAD (to Q.L.), a grant from the California Institute for Regenerative Medicine (RFA 09-02), and funding from the Howard Hughes Medical Institute. D.L.B. is an investigator of the HHMI. We declare no financial interests in any of the work described.",

year = "2012",

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doi = "10.3109/10409238.2012.691456",

language = "English (US)",

volume = "47",

pages = "360--378",

journal = "Critical reviews in biochemistry and molecular biology",

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AU - Keppetipola, Niroshika

AU - Sharma, Shalini

AU - Li, Qin

AU - Black, Douglas L.

N1 - Funding Information: Our own work has been supported by NIH Grants RO1 GM49662, R24 GM070857 (to D.L.B.), fellowship and training grant support from an NRSA and 5T32 NS07449 (to N.K.) and from NARSAD (to Q.L.), a grant from the California Institute for Regenerative Medicine (RFA 09-02), and funding from the Howard Hughes Medical Institute. D.L.B. is an investigator of the HHMI. We declare no financial interests in any of the work described.

PY - 2012/7

Y1 - 2012/7

N2 - Alternative splicing patterns are regulated by RNA binding proteins that assemble onto each pre-mRNA to form a complex RNP structure. The polypyrimidine tract binding protein, PTB, has served as an informative model for understanding how RNA binding proteins affect spliceosome assembly and how changes in the expression of these proteins can control complex programs of splicing in tissues. In this review, we describe the mechanisms of splicing regulation by PTB and its function, along with its paralog PTBP2, in neuronal development.

AB - Alternative splicing patterns are regulated by RNA binding proteins that assemble onto each pre-mRNA to form a complex RNP structure. The polypyrimidine tract binding protein, PTB, has served as an informative model for understanding how RNA binding proteins affect spliceosome assembly and how changes in the expression of these proteins can control complex programs of splicing in tissues. In this review, we describe the mechanisms of splicing regulation by PTB and its function, along with its paralog PTBP2, in neuronal development.

KW - Alternative splicing

KW - Neuronal development

KW - RNA binding protein

KW - RNP

KW - Spliceosome

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UR - https://www.scopus.com/pages/publications/84862679962#tab=citedBy

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DO - 10.3109/10409238.2012.691456

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VL - 47

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Neuronal regulation of pre-mRNA splicing by polypyrimidine tract binding proteins, PTBP1 and PTBP2

Abstract

Keywords

ASJC Scopus subject areas

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