@inbook{136fe267e2a54a67a889e439b9ae6c9f,
title = "Neuroinflammation and Tinnitus",
abstract = "Neuroinflammation is the central nervous system{\textquoteright}s response to: injury, infection, and abnormal neural activity. Inflammatory processes are known to mediate many diseases, and recently evidence indicates that neuroinflammation underlies hearing disorders such as presbyacusis, middle-ear disease, ototoxicity, noise-induced hearing loss, and tinnitus. This chapter provides a review of the role of neuroinflammation in the etiology and treatment of tinnitus. Specifically, our research team has demonstrated that both tumor necrosis factor alpha (TNF-α) and calpain signaling pathways are involved in noise-induced tinnitus and that blocking them yielded therapeutic effects on tinnitus. Other efforts such as controlling acute inflammatory response via specialized pro-resolving mediators may help provide insight into preventing and treating tinnitus-related inflammatory processes.",
keywords = "Inflammatopathy, Microglia specific pro-resolving mediator, Neuroinflammation, Tumor necrosis factor alpha (TNF-α) calpain",
author = "Abraham Shulman and Weihua Wang and Hao Luo and Shaowen Bao and Grant Searchfield and Jinsheng Zhang",
note = "Funding Information: Acknowledgements This work was supported by the US Department of Defense (W81XWH-15-1-0028, W81XWH-15-1-0356, W81XWH-15-1-0357) and Martha Entenmann Tinnitus Research Center. The support of Richard M. Rosenfeld, M.D., and Matthew B. Hanson M.D. in tinnitus interest and efforts is appreciated. Publisher Copyright: {\textcopyright} 2021, Springer Nature Switzerland AG.",
year = "2021",
doi = "10.1007/7854\_2021\_238",
language = "English (US)",
series = "Current Topics in Behavioral Neurosciences",
publisher = "Springer Science and Business Media Deutschland GmbH",
pages = "161--174",
booktitle = "Current Topics in Behavioral Neurosciences",
address = "Germany",
}