Neuroinflammation and Tinnitus

Abraham Shulman, Weihua Wang, Hao Luo, Shaowen Bao, Grant Searchfield, Jinsheng Zhang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Neuroinflammation is the central nervous system’s response to: injury, infection, and abnormal neural activity. Inflammatory processes are known to mediate many diseases, and recently evidence indicates that neuroinflammation underlies hearing disorders such as presbyacusis, middle-ear disease, ototoxicity, noise-induced hearing loss, and tinnitus. This chapter provides a review of the role of neuroinflammation in the etiology and treatment of tinnitus. Specifically, our research team has demonstrated that both tumor necrosis factor alpha (TNF-α) and calpain signaling pathways are involved in noise-induced tinnitus and that blocking them yielded therapeutic effects on tinnitus. Other efforts such as controlling acute inflammatory response via specialized pro-resolving mediators may help provide insight into preventing and treating tinnitus-related inflammatory processes.

Original languageEnglish (US)
Title of host publicationCurrent Topics in Behavioral Neurosciences
PublisherSpringer Science and Business Media Deutschland GmbH
Pages161-174
Number of pages14
DOIs
StatePublished - 2021

Publication series

NameCurrent Topics in Behavioral Neurosciences
Volume51
ISSN (Print)1866-3370
ISSN (Electronic)1866-3389

Keywords

  • Inflammatopathy
  • Microglia specific pro-resolving mediator
  • Neuroinflammation
  • Tumor necrosis factor alpha (TNF-α) calpain

ASJC Scopus subject areas

  • Behavioral Neuroscience

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