Neuroimaging of Parkinson's disease: Expanding views

Carol P. Weingarten, Mark H. Sundman, Patrick Hickey, Nan kuei Chen

Research output: Contribution to journalReview articlepeer-review

86 Scopus citations

Abstract

Advances in molecular and structural and functional neuroimaging are rapidly expanding the complexity of neurobiological understanding of Parkinson's disease (PD). This review article begins with an introduction to PD neurobiology as a foundation for interpreting neuroimaging findings that may further lead to more integrated and comprehensive understanding of PD. Diverse areas of PD neuroimaging are then reviewed and summarized, including positron emission tomography, single photon emission computed tomography, magnetic resonance spectroscopy and imaging, transcranial sonography, magnetoencephalography, and multimodal imaging, with focus on human studies published over the last five years. These included studies on differential diagnosis, co-morbidity, genetic and prodromal PD, and treatments from l-DOPA to brain stimulation approaches, transplantation and gene therapies. Overall, neuroimaging has shown that PD is a neurodegenerative disorder involving many neurotransmitters, brain regions, structural and functional connections, and neurocognitive systems. A broad neurobiological understanding of PD will be essential for translational efforts to develop better treatments and preventive strategies. Many questions remain and we conclude with some suggestions for future directions of neuroimaging of PD.

Original languageEnglish (US)
Pages (from-to)16-52
Number of pages37
JournalNeuroscience and Biobehavioral Reviews
Volume59
DOIs
StatePublished - Dec 1 2015
Externally publishedYes

Keywords

  • Brain imaging
  • DTI
  • Diffusion tensor imaging
  • FMRI
  • Functional connectivity
  • MEG
  • MRI
  • MRS
  • Magnetic resonance imaging
  • Neuroimaging
  • PET
  • Parkinson's disease
  • Positron emission tomography
  • SPECT
  • TCS

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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