Neuroendocrine-immune interactions: Implications for health and behavior

T. W.W. Pace, C. L. Raison, A. H. Miller

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


Over the past several decades, an immense body of data has been gathered which convincingly demonstrates that the nervous, endocrine, and immune systems interact in meaningful ways that influence the maintenance of health and the development of disease. While early studies focused on the impact of nervous and endocrine system factors on immune regulation, intriguing new data on the effects of the immune system on nervous system function indicate that the communication pathways between the nervous and immune systems are bidirectional. Moreover, increasing data from clinical studies suggest that these communication pathways may be relevant to the development, course, and outcome of both immune-related and neuropsychiatric diseases. In this chapter, we will review the body of data that substantiates interactions among the nervous, endocrine, and immune systems, and will integrate these data into a model of the role of neuroendocrine-immune interactions in health and illness.

Original languageEnglish (US)
Title of host publicationHormones, Brain and Behavior Online
PublisherElsevier Inc.
Number of pages38
ISBN (Print)9780080887838
StatePublished - 2009


  • Acquired immune system
  • Acute stress
  • Chronic stress
  • Cytokines
  • Endocrine system
  • Glucocorticoid receptor
  • Hypothalamic-pituitary-adrenal axis
  • Immunotherapy
  • Inflammation
  • Innate immune system
  • Major depression
  • NFκB
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Neuroscience(all)


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