@inbook{5e57fba3c6cd4995b20d7b56f3456be0,
title = "Neuroendocrine-immune interactions: Implications for health and behavior",
abstract = "Over the past several decades, an immense body of data has been gathered which convincingly demonstrates that the nervous, endocrine, and immune systems interact in meaningful ways that influence the maintenance of health and the development of disease. While early studies focused on the impact of nervous and endocrine system factors on immune regulation, intriguing new data on the effects of the immune system on nervous system function indicate that the communication pathways between the nervous and immune systems are bidirectional. Moreover, increasing data from clinical studies suggest that these communication pathways may be relevant to the development, course, and outcome of both immune-related and neuropsychiatric diseases. In this chapter, we will review the body of data that substantiates interactions among the nervous, endocrine, and immune systems, and will integrate these data into a model of the role of neuroendocrine-immune interactions in health and illness.",
keywords = "Acquired immune system, Acute stress, Chronic stress, Cytokines, Endocrine system, Glucocorticoid receptor, Hypothalamic-pituitary-adrenal axis, Immunotherapy, Inflammation, Innate immune system, Major depression, NFκB, Sympathetic nervous system",
author = "Pace, {T. W.W.} and Raison, {Charles L} and Miller, {A. H.}",
note = "Funding Information: Dr. Pace is assistant professor of psychiatry and behavioral sciences in the School of Medicine at Emory University in Atlanta, Georgia. He is also a member of the neuroscience faculty in the Graduate Division of Biological and Biomedical Sciences at Emory. He received his BS in psychobiology from Albright College, and his PhD in neuroscience and psychology from the University of Colorado at Boulder. At Colorado Dr. Pace studied regulatory mechanisms of resting and stress-induced hypothalamic–pituitary–adrenal axis function in the laboratory of Robert L. Spencer, PhD. His work at Emory explores endocrine and immune system function in people who suffer from major depression, as well as endocrine and inflammatory immune changes that result from adverse experiences during the formative years of life. Dr. Pace also investigates the effectiveness of novel interventions that may optimize inflammatory immune and endocrine responses to stress, such as the practice of compassion meditation (in collaboration with Charles Raison, MD), and novel anti-inflammatory compounds (in collaboration with Andrew H. Miller, MD, Hyunsuk Shim, PhD, and Dennis C. Liotta, PhD). Dr. Pace is the recipient of a NARSAD young investigator award, and his research is also supported by grants from the National Institute of Mental Health. Funding Information: Dr. Charles Raison is an assistant professor in the Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine. He also serves as clinical director of the Mind-Body program and co-director of the Collaborative for Contemplative Studies at the University. Dr. Raison received his medical degree from Washington University in St. Louis, MO, where he was elected to Alpha Omega Alpha and won the Missouri State Medical Association Award. He completed residency training at the UCLA Neuropsychiatric Institute and Hospital in Los Angeles. Dr. Raison served as director of emergency psychiatric services and associate director of consultation and evaluation services at UCLA prior to joining the faculty at Emory University. The recipient of several teaching awards, Dr. Raison receives research funding from the National Institute of Mental Health and the Centers for Disease Control and Prevention. His research focuses on bidirectional relationships between stress and immune systems, especially as these pertain to depression in the medically ill. His research ranges from immune system effects on central nervous system functioning to the application of compassion meditation as a strategy to prevent depressive symptoms in college students via reduction in stress-related inflammatory activity. He is also internationally recognized for his expertise in the diagnosis and treatment of interferon-alpha-induced depression and anxiety. Funding Information: Dr. Andrew Miller is William P. Timmie professor of psychiatry and behavioral sciences and director of psychiatric oncology at the Winship Cancer Institute. Dr. Miller attended the Medical College of Georgia and did a residency in psychiatry at the Albert Einstein College of Medicine. As a junior faculty member, Dr. Miller trained with Dr. Marvin Stein at Mount Sinai School of Medicine and Dr. Bruce McEwen at Rockefeller University. Dr. Miller's work focuses on the impact of the activated innate immune system on behavior and health. He is also interested in the role of glucocorticoids in the regulation of inflammatory responses. Dr. Miller has published over 120 manuscripts in scholarly journals. Dr. Miller currently has studies funded by the National Institute of Mental Health, the Centers for Disease Control and Prevention, and pharmaceutical companies to examine mechanism and treatment of cytokine-induced depression. His studies with interferon-alpha provide a model to understand and treat depression, fatigue, and cognitive dysfunction in medically ill patients. Dr. Miller is a Board Certified Psychiatrist and an examiner for the American Board of Psychiatry and Neurology. He is also the recipient of three teaching awards, an NARSAD Independent Investigator Award, and an NIMH Research Scientist Development Award, which he has held for the past 20 years.",
year = "2009",
doi = "10.1016/B978-008088783-8.00083-8",
language = "English (US)",
isbn = "9780080887838",
pages = "2597--2634",
booktitle = "Hormones, Brain and Behavior Online",
publisher = "Elsevier Inc.",
}