Neuroendocrine Aging: Hypothalamic-Pituitary-Gonadal Axis in Women

N. E. Rance

doi:10.1016/B978-008045046-9.00115-7

Neuroendocrine Aging: Hypothalamic-Pituitary-Gonadal Axis in Women

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Menopause constitutes one of the most dramatic and consistent aging changes in humans. The hallmark of reproductive aging is degeneration of ovarian follicles, which accelerates during the fourth decade of life. The earliest hormone marker of reproductive aging is elevated serum follicle-stimulating hormone, which is inversely correlated with inhibin B secretion from developing follicles. A prolonged menopausal transition, characterized by irregular cycles and fluctuating hormone levels, is followed by the cessation of reproductive cycles. In the postmenopausal period, the reproductive neuroendocrine axis is strongly influenced by the withdrawal of the negative feedback effects of ovarian hormones. In addition, there is evidence of aging of the hypothalamic-pituitary axis in women that is independent from the changes in gonadal status.

Original language	English (US)
Title of host publication	Encyclopedia of Neuroscience
Publisher	Elsevier Ltd.
Pages	291-297
Number of pages	7
ISBN (Print)	9780080450469
DOIs	https://doi.org/10.1016/B978-008045046-9.00115-7
State	Published - 2009

Keywords

Estrogen
FSH
GnRH
Gonadal feedback
Hypothalamus
Inhibin
LH
Menopause
Neuroendocrine
Neurokinin B
Ovary
Reproduction

ASJC Scopus subject areas

General Neuroscience

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10.1016/B978-008045046-9.00115-7

Cite this

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abstract = "Menopause constitutes one of the most dramatic and consistent aging changes in humans. The hallmark of reproductive aging is degeneration of ovarian follicles, which accelerates during the fourth decade of life. The earliest hormone marker of reproductive aging is elevated serum follicle-stimulating hormone, which is inversely correlated with inhibin B secretion from developing follicles. A prolonged menopausal transition, characterized by irregular cycles and fluctuating hormone levels, is followed by the cessation of reproductive cycles. In the postmenopausal period, the reproductive neuroendocrine axis is strongly influenced by the withdrawal of the negative feedback effects of ovarian hormones. In addition, there is evidence of aging of the hypothalamic-pituitary axis in women that is independent from the changes in gonadal status.",

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KW - FSH

KW - GnRH

KW - Gonadal feedback

KW - Hypothalamus

KW - Inhibin

KW - LH

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KW - Neuroendocrine

KW - Neurokinin B

KW - Ovary

KW - Reproduction

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BT - Encyclopedia of Neuroscience

PB - Elsevier Ltd.

ER -

Neuroendocrine Aging: Hypothalamic-Pituitary-Gonadal Axis in Women

Abstract

Keywords

ASJC Scopus subject areas

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