Abstract
In recent decades, obesity has become a pandemic disease and appears to be an ultimate medical and social problem. Existing antiobesity drugs show low efficiency and a wide variety of side effects. In this review, we discuss possible mechanisms underlying brain-gut-adipose tissue axis, as well as molecular biochemical characteristics of various neurochemical regulators of body weight and appetite. Multiple brain regions are responsible for eating behavior, hedonic eating and food addiction. The existing pharmacological targets for treatment of obesity were reviewed as well.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1865-1884 |
| Number of pages | 20 |
| Journal | Future Medicinal Chemistry |
| Volume | 12 |
| Issue number | 20 |
| DOIs | |
| State | Published - Oct 2020 |
Keywords
- anti-obesity drugs
- hypothalamus
- neurochemical regulators
- obesity
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology
- Drug Discovery
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