Neurochemical regulators of food behavior for pharmacological treatment of obesity: current status and future prospects

Gayane Sargis Vardanyan, Hasmik Samvel Harutyunyan, Michail Iosif Aghajanov, Ruben Sargis Vardanyan

Research output: Contribution to journalReview articlepeer-review

Abstract

In recent decades, obesity has become a pandemic disease and appears to be an ultimate medical and social problem. Existing antiobesity drugs show low efficiency and a wide variety of side effects. In this review, we discuss possible mechanisms underlying brain-gut-adipose tissue axis, as well as molecular biochemical characteristics of various neurochemical regulators of body weight and appetite. Multiple brain regions are responsible for eating behavior, hedonic eating and food addiction. The existing pharmacological targets for treatment of obesity were reviewed as well.

Original languageEnglish (US)
Pages (from-to)1865-1884
Number of pages20
JournalFuture Medicinal Chemistry
Volume12
Issue number20
DOIs
StatePublished - Oct 2020

Keywords

  • anti-obesity drugs
  • hypothalamus
  • neurochemical regulators
  • obesity

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

Fingerprint

Dive into the research topics of 'Neurochemical regulators of food behavior for pharmacological treatment of obesity: current status and future prospects'. Together they form a unique fingerprint.

Cite this