TY - JOUR
T1 - Neurochemical regulators of food behavior for pharmacological treatment of obesity
T2 - current status and future prospects
AU - Vardanyan, Gayane Sargis
AU - Harutyunyan, Hasmik Samvel
AU - Aghajanov, Michail Iosif
AU - Vardanyan, Ruben Sargis
N1 - Funding Information:
This work was supported by the RA MESCS State Committee of Science, in the frames of the research project no. 18T-1F095. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
Publisher Copyright:
© 2020 Newlands Press.
PY - 2020/10
Y1 - 2020/10
N2 - In recent decades, obesity has become a pandemic disease and appears to be an ultimate medical and social problem. Existing antiobesity drugs show low efficiency and a wide variety of side effects. In this review, we discuss possible mechanisms underlying brain-gut-adipose tissue axis, as well as molecular biochemical characteristics of various neurochemical regulators of body weight and appetite. Multiple brain regions are responsible for eating behavior, hedonic eating and food addiction. The existing pharmacological targets for treatment of obesity were reviewed as well.
AB - In recent decades, obesity has become a pandemic disease and appears to be an ultimate medical and social problem. Existing antiobesity drugs show low efficiency and a wide variety of side effects. In this review, we discuss possible mechanisms underlying brain-gut-adipose tissue axis, as well as molecular biochemical characteristics of various neurochemical regulators of body weight and appetite. Multiple brain regions are responsible for eating behavior, hedonic eating and food addiction. The existing pharmacological targets for treatment of obesity were reviewed as well.
KW - anti-obesity drugs
KW - hypothalamus
KW - neurochemical regulators
KW - obesity
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U2 - 10.4155/fmc-2019-0361
DO - 10.4155/fmc-2019-0361
M3 - Review article
C2 - 33040605
AN - SCOPUS:85094932329
VL - 12
SP - 1865
EP - 1884
JO - Future Medicinal Chemistry
JF - Future Medicinal Chemistry
SN - 1756-8919
IS - 20
ER -