Neurochemical perspectives of the narcoleptic syndrome

R. Sandyk, C. Bamford, E. Labadie

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Narcolepsy has been defined as a disorder of excessive sleep often associated with cataplexy, sleep paralysis and hypnagogic hallucinations. Although the pathophysiology of the narcoleptic syndrome is not well understood, derangement in the functions of CNS catecholamines and serotonin (5-HT) have been implicated. In the present paper we summarize evidence to suggest a role for the endogenous opioids in the regulation of normal sleep and in the pathophysiology of the narcoleptic syndrome.

Original languageEnglish (US)
Pages (from-to)21-30
Number of pages10
JournalInternational Journal of Neuroscience
Issue number1-2
StatePublished - 1988


  • Narcolepsy
  • Noradrenaline
  • Opioids
  • REM sleep
  • Serotonin

ASJC Scopus subject areas

  • General Neuroscience


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