Neurochemical challenge

Michael L. Heien; Jonathan V. Sweedler

doi:10.1007/s00216-006-0932-1

Neurochemical challenge

Michael L. Heien, Jonathan V. Sweedler

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The effect of neurotransmitters on the firing pattern of the postsynaptic cells with which the new neuronal type forms a synapse was investigated. Two sensors capable of detecting the different neurotransmitters which is an electrochemical sensor for neurotransmitter A and a cannula interfaced with capillary electrophoresis for detection of neurotransmitter B was developed. To determine the biological function of the neurotransmitter the electrical output of the circuit as a response to an input stimulus was measured. The detection limit of neurotransmitter A was limited to 40 nmol L^-1 and the detection limit of the neurotransmitter B was 80 nmol L^-1. the closest position of the dual sensor was approximately 5 μm from the synapse.

Original language	English (US)
Pages (from-to)	3-4
Number of pages	2
Journal	Analytical and bioanalytical chemistry
Volume	387
Issue number	1
DOIs	https://doi.org/10.1007/s00216-006-0932-1
State	Published - Jan 2007
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry

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10.1007/s00216-006-0932-1

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Neurochemical challenge

Abstract

ASJC Scopus subject areas

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