Neurobiology of Down Syndrome

Stella Sakhon, Jamie Edgin

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Differences in the brain of individuals with Down syndrome (DS) are demonstrated as early as the fetal period and progress through adulthood. Although the cognitive and behavioral phenotype of DS is well characterized in some discrete age ranges, more information is required about developmental trajectories in this population. Advancements in technology and available animal models have aided in the accumulation of information about cognitive and neural development, including the development of Alzheimer's disease, in DS. However, there are still open questions such as how early in development those with DS may suffer from the impact of Alzheimer's disease progression and what factors predict those with more typical versus atypical developmental trajectories. These questions are important to answer given the backdrop of active neuro-therapeutic clinical trials in this population.

Original languageEnglish (US)
Title of host publicationThe Wiley Encyclopedia of Health Psychology
Subtitle of host publicationBiological Bases of Health Behavior: Volume 1, The Social Bases of Health Behavior: Volume 2, Clinical Health Psychology and Behavioral Medicine: Volume 3, Special Issues in Health Psychology: Volume 4
PublisherWiley
PagesV1:197-V1:203
ISBN (Electronic)9781119057840
ISBN (Print)9781119057833
DOIs
StatePublished - Jan 1 2020
Externally publishedYes

Keywords

  • aging
  • Alzheimer's disease
  • brain structures
  • development
  • Down syndrome
  • mouse models
  • neuroimaging
  • sleep
  • treatment

ASJC Scopus subject areas

  • General Psychology

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