Neural aspects of fatigue

Fatigue brought about by intense muscular contraction typically is accompanied by a reduction in motor-unit firing rate. The decrease in motor-unit output with fatigue appears to be caused by two interacting processes: 1) a decline in the net excitatory drive to motoneurons and 2) adaptation in the responsiveness of motoneurons to synaptic input. Whether a reduction in motor-unit firing rate in itself contributes to force loss associated with fatigue, however, is an unresolved question. The neuromuscular wisdom hypothesis suggests that decreases in firing rate help to maintain force by optimizing the input to motor units as their contractile properties change. On the other hand, recent work indicates that mechanical function of some motor units is altered during prolonged activity such that diminished firing rate would augment force loss and, thereby, contribute to fatigue. Neural adaptations, therefore, may serve to limit the extent of muscular activity.