Network-centered view of coronary artery disease

Brian J. Bennett, Casey E. Romanoski, Aldons J. Lusis

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Systems biology is an emerging field that attempts to examine multiple elements of a biologic system using techniques such as expression microarrays or proteomics. The goal of systems biology is to detect all the elements of a system and create an interaction network between these so that the system can be explained under specified conditions. In this review we discuss how systems-based approaches are being applied to cardiovascular disease, illustrating concepts, such as the integration of orthogonal datasets, coexpression networks and emergent properties.

Original languageEnglish (US)
Pages (from-to)1095-1103
Number of pages9
JournalExpert review of cardiovascular therapy
Issue number6
StatePublished - Nov 2007
Externally publishedYes


  • Biologic networks
  • Coronary artery disease
  • Genomics
  • Proteomics
  • Systems biology

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine


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