NCAM (CD56)-positive malignant lymphoma

W. F. Kern, C. M. Spier, T. P. Miller, T. M. Grogan

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


CD56 has been found to identify an isoform of the neural cell adhesion (NCAM). NCAM is a member of the immunoglobulin superfamily of cell adhesion molecules; it is related to a variety of leukocyte antigens and to several cell adhesion molecules believed relevant to malignant behavior in a variety of neoplasms. It contains poly sialic acid, which appears to regulate binding avidity of NCAM and other cell adhesion processes. We have identified a group of NCAM-positive lymphomas. Compared to a group of NCAM-negative lymphomas, this group exhibited frequent involvement of unusual sites and a generally aggressive course. Another series of CD56-positive hematolymphoid malignancies has recently been described, from Hong Kong; this group also exhibited involvement of unusual sites and displayed a very aggressive course. Together these series suggest that NCAM on lymphoma is of biological and clinical significance in terms of tumor behavior and spread.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalLeukemia and Lymphoma
Issue number1-2
StatePublished - 1993


  • CD56
  • Cell adhesion molecules
  • Localization
  • Malignant lymphoma
  • Neural cell adhesion molecule
  • Polysialic acid

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research


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