TY - JOUR
T1 - Natural dissolved organic matter affects electrospray ionization during analysis of emerging contaminants by mass spectrometry
AU - Wickramasekara, Samanthi
AU - Hernández-Ruiz, Selene
AU - Abrell, Leif
AU - Arnold, Robert G
AU - Chorover, Jon
N1 - Funding Information:
Research support was provided by the Water Research Foundation (Award #4269), the Binational Agricultural Research and Development (BARD) fund (Grant # IS-3822-06 ), and University of Arizona Water Sustainability Program . The comments and views detailed herein may not necessarily reflect the views of the Water Research Foundation, its officers, directors, affiliates, or agents. Analyses in the Arizona Laboratory for Emerging Contaminants were supported by NSF CBET 0722579 .
PY - 2012/3/2
Y1 - 2012/3/2
N2 - Dissolved organic matter (DOM), present in many forms in water, can interfere with analysis of organic contaminants by atmospheric pressure ionization-mass spectrometry. A quantitative analysis of this interference, or matrix effect, on organic contaminant target analyte measurements was carried out using un-fractionated and fractionated dissolved natural organic matter from the Suwannee River, GA (SROM), a standard reference material, that was directly infused into the tandem mass spectrometer during multiple reaction monitoring (MRM) of a suite of endocrine disrupting compounds-pharmaceuticals and personal care products (EDC/PPCPs). Most target analytes suffered signal suppression in the presence of both fractionated and un-fractionated SROM, however greater interferences were measured with fractionated relative to bulk SROM. This finding is consistent with the view of organic matter as a supramolecular association of low molecular mass components having separate charged and structural features revealed only after dissociation.
AB - Dissolved organic matter (DOM), present in many forms in water, can interfere with analysis of organic contaminants by atmospheric pressure ionization-mass spectrometry. A quantitative analysis of this interference, or matrix effect, on organic contaminant target analyte measurements was carried out using un-fractionated and fractionated dissolved natural organic matter from the Suwannee River, GA (SROM), a standard reference material, that was directly infused into the tandem mass spectrometer during multiple reaction monitoring (MRM) of a suite of endocrine disrupting compounds-pharmaceuticals and personal care products (EDC/PPCPs). Most target analytes suffered signal suppression in the presence of both fractionated and un-fractionated SROM, however greater interferences were measured with fractionated relative to bulk SROM. This finding is consistent with the view of organic matter as a supramolecular association of low molecular mass components having separate charged and structural features revealed only after dissociation.
KW - Dissolved organic matter
KW - Electrospray ionization
KW - Endocrine disrupting chemicals (EDCs)
KW - Matrix effect
KW - Pharmaceuticals and personal care products (PPCPs)
KW - Ultra high pressure liquid chromatography-tandem mass spectrometry (UHPLC-MSMS)
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U2 - 10.1016/j.aca.2011.12.019
DO - 10.1016/j.aca.2011.12.019
M3 - Article
C2 - 22304818
AN - SCOPUS:84856502474
SN - 0003-2670
VL - 717
SP - 77
EP - 84
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
ER -