Na+/H+ Exchange in Mammalian Digestive Tract

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Abstract

The Slc9a family of Na+/H+ exchangers (NHEs) plays a critical role in neutral sodium absorption in the mammalian intestine as well as other absorptive and secretory epithelia of digestive organs. These transport proteins mediate the electroneutral exchange of Na+ and H+ and are crucial in a variety of physiological processes, including the transepithelial Na+ and water absorption, fine tuning of intracellular pH, cell volume control and systemic electrolyte, and acid-base and fluid volume homeostasis. They also secondarily affect other cellular transport mechanisms as well as cell survival, motility, adhesion, and repair mechanisms. In this chapter, we review the role of the Na+/H+ exchange mechanism as it relates to the physiology of organs and cells involved in nutrient intake and absorption, and we describe physiological and molecular aspects of individual isoforms, including their structure, tissue-, and subcellular distribution, as well as their regulation by physiological stimuli at the transcriptional and posttranscriptional levels. Consequences of gene-targeted mutation of individual isoforms are discussed in the context of the physiology of digestive organs. Where available, we also provide a review of pathophysiological states related to aberrant expression and/or activity of NHEs within the confines of the digestive system.

Original languageEnglish (US)
Title of host publicationPhysiology of the Gastrointestinal Tract, Sixth Edition
PublisherElsevier
Pages1273-1316
Number of pages44
Volume2
ISBN (Electronic)9780128099544
ISBN (Print)9780128124260
DOIs
StatePublished - Jan 1 2018

Keywords

  • Antiporter
  • Epithelium
  • Intracellular pH
  • Membrane transport
  • Na absorption
  • Na/H exchanger gene family
  • SLC9

ASJC Scopus subject areas

  • General Medicine

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