Nanofibrous lipid membranes capable of functionally immobilizing antibodies and capturing specific cells

Zhengbao Zha; Celine Cohn; Zhifei Dai; Weiguo Qiu; Jinhong Zhang; Xiaoyi Wu

doi:10.1002/adma.201101516

Nanofibrous lipid membranes capable of functionally immobilizing antibodies and capturing specific cells

Zhengbao Zha, Celine Cohn, Zhifei Dai, Weiguo Qiu, Jinhong Zhang, Xiaoyi Wu

Mining and Geological Engineering

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Polymerizable cholesteryl-succinyl silane was synthesized and fabricated into stable nanofibrous lipid membranes using a combined sol-gel and electrospinning process. The resulting nanofibrous lipid membranes are capable of functionally immobilizing membrane proteins such as antibodies, thereby enabling targeted cell capture via the antigen-antibody interactions.

Original language	English (US)
Pages (from-to)	3435-3440
Number of pages	6
Journal	Advanced Materials
Volume	23
Issue number	30
DOIs	https://doi.org/10.1002/adma.201101516
State	Published - Aug 9 2011

Keywords

Lipid nanofibers
antibody immobilization
cell capture
cholesterol

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.201101516

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abstract = "Polymerizable cholesteryl-succinyl silane was synthesized and fabricated into stable nanofibrous lipid membranes using a combined sol-gel and electrospinning process. The resulting nanofibrous lipid membranes are capable of functionally immobilizing membrane proteins such as antibodies, thereby enabling targeted cell capture via the antigen-antibody interactions.",

keywords = "Lipid nanofibers, antibody immobilization, cell capture, cholesterol",

author = "Zhengbao Zha and Celine Cohn and Zhifei Dai and Weiguo Qiu and Jinhong Zhang and Xiaoyi Wu",

year = "2011",

month = aug,

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doi = "10.1002/adma.201101516",

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journal = "Advanced Materials",

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T1 - Nanofibrous lipid membranes capable of functionally immobilizing antibodies and capturing specific cells

AU - Zha, Zhengbao

AU - Cohn, Celine

AU - Dai, Zhifei

AU - Qiu, Weiguo

AU - Zhang, Jinhong

AU - Wu, Xiaoyi

PY - 2011/8/9

Y1 - 2011/8/9

N2 - Polymerizable cholesteryl-succinyl silane was synthesized and fabricated into stable nanofibrous lipid membranes using a combined sol-gel and electrospinning process. The resulting nanofibrous lipid membranes are capable of functionally immobilizing membrane proteins such as antibodies, thereby enabling targeted cell capture via the antigen-antibody interactions.

AB - Polymerizable cholesteryl-succinyl silane was synthesized and fabricated into stable nanofibrous lipid membranes using a combined sol-gel and electrospinning process. The resulting nanofibrous lipid membranes are capable of functionally immobilizing membrane proteins such as antibodies, thereby enabling targeted cell capture via the antigen-antibody interactions.

KW - Lipid nanofibers

KW - antibody immobilization

KW - cell capture

KW - cholesterol

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U2 - 10.1002/adma.201101516

DO - 10.1002/adma.201101516

M3 - Article

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AN - SCOPUS:80051692565

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JO - Advanced Materials

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IS - 30

ER -

Nanofibrous lipid membranes capable of functionally immobilizing antibodies and capturing specific cells

Abstract

Keywords

ASJC Scopus subject areas

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