Nanocrystals for the parenteral delivery of poorly water-soluble drugs

Bo Sun; Yoon Yeo

doi:10.1016/j.cossms.2012.10.004

Nanocrystals for the parenteral delivery of poorly water-soluble drugs

Bo Sun, Yoon Yeo

Research output: Contribution to journal › Review article › peer-review

121 Scopus citations

Abstract

Nanocrystals have drawn increasing interest in pharmaceutical industry because of the ability to improve dissolution of poorly water-soluble drugs. Nanocrystals can be produced by top-down and bottom-up technologies and have been explored for a variety of therapeutic applications. Here we review the methods of nanocrystal production and parenteral applications of nanocrystals. We also discuss remaining challenges in the development of nanocrystal products.

Original language	English (US)
Pages (from-to)	295-301
Number of pages	7
Journal	Current Opinion in Solid State and Materials Science
Volume	16
Issue number	6
DOIs	https://doi.org/10.1016/j.cossms.2012.10.004
State	Published - Dec 2012
Externally published	Yes

Keywords

Nanocrystals
Nanosuspension
Parenteral applications
Poorly water-soluble drugs

ASJC Scopus subject areas

General Materials Science

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10.1016/j.cossms.2012.10.004

Cite this

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title = "Nanocrystals for the parenteral delivery of poorly water-soluble drugs",

abstract = "Nanocrystals have drawn increasing interest in pharmaceutical industry because of the ability to improve dissolution of poorly water-soluble drugs. Nanocrystals can be produced by top-down and bottom-up technologies and have been explored for a variety of therapeutic applications. Here we review the methods of nanocrystal production and parenteral applications of nanocrystals. We also discuss remaining challenges in the development of nanocrystal products.",

keywords = "Nanocrystals, Nanosuspension, Parenteral applications, Poorly water-soluble drugs",

author = "Bo Sun and Yoon Yeo",

note = "Funding Information: This work was supported by NSF DMR-1056997, NIH R21 CA135130, a Grant from the Lilly Endowment, Inc. to College of Pharmacy, Purdue University, and Intramural Research Program (Global RNAi Carrier Initiative) of Korea Institute of Science and Technology.",

year = "2012",

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journal = "Current Opinion in Solid State and Materials Science",

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T1 - Nanocrystals for the parenteral delivery of poorly water-soluble drugs

AU - Sun, Bo

AU - Yeo, Yoon

N1 - Funding Information: This work was supported by NSF DMR-1056997, NIH R21 CA135130, a Grant from the Lilly Endowment, Inc. to College of Pharmacy, Purdue University, and Intramural Research Program (Global RNAi Carrier Initiative) of Korea Institute of Science and Technology.

PY - 2012/12

Y1 - 2012/12

N2 - Nanocrystals have drawn increasing interest in pharmaceutical industry because of the ability to improve dissolution of poorly water-soluble drugs. Nanocrystals can be produced by top-down and bottom-up technologies and have been explored for a variety of therapeutic applications. Here we review the methods of nanocrystal production and parenteral applications of nanocrystals. We also discuss remaining challenges in the development of nanocrystal products.

AB - Nanocrystals have drawn increasing interest in pharmaceutical industry because of the ability to improve dissolution of poorly water-soluble drugs. Nanocrystals can be produced by top-down and bottom-up technologies and have been explored for a variety of therapeutic applications. Here we review the methods of nanocrystal production and parenteral applications of nanocrystals. We also discuss remaining challenges in the development of nanocrystal products.

KW - Nanocrystals

KW - Nanosuspension

KW - Parenteral applications

KW - Poorly water-soluble drugs

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UR - http://www.scopus.com/inward/citedby.url?scp=84875242104&partnerID=8YFLogxK

U2 - 10.1016/j.cossms.2012.10.004

DO - 10.1016/j.cossms.2012.10.004

M3 - Review article

AN - SCOPUS:84875242104

SN - 1359-0286

VL - 16

SP - 295

EP - 301

JO - Current Opinion in Solid State and Materials Science

JF - Current Opinion in Solid State and Materials Science

IS - 6

ER -

Nanocrystals for the parenteral delivery of poorly water-soluble drugs

Abstract

Keywords

ASJC Scopus subject areas

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