Naltrindole, an opioid delta receptor antagonist, blocks cocaine-induced facilitation of responding for rewarding brain stimulation

Larry D. Reid; Christopher L. Hubbell; Matthew B. Glaccum; Edward J. Bilsky; Philip S. Portoghese; Frank Porreca

doi:10.1016/0024-3205(93)90084-G

Naltrindole, an opioid delta receptor antagonist, blocks cocaine-induced facilitation of responding for rewarding brain stimulation

Larry D. Reid, Christopher L. Hubbell, Matthew B. Glaccum, Edward J. Bilsky, Philip S. Portoghese, Frank Porreca

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Recent experimental results have led to the suggestion that opioid antagonists can modulate the reinforcing properties of cocaine. In this experiment, rats were fixed with chronically indwelling bipolar electrodes for stimulation of the medial forebrain bundle (MFB) as it courses through the hypothalamus. Rats were taught to press a lever for brief trains of electrical stimulation of the MFB. Subsequently, they were allowed to press for varying intensities of stimulation daily until their response rates were stable. Cocaine (5 mg/kg, s.c.) enhanced the rate of pressing for lower intensities of brain stimulation. Naltrindole (3 mg/kg, i.p.) had no effect on response rate alone but blocked the cocaine-induced facilitation of pressing for rewarding brain stimulation. An implication that can be drawn from these data is that naltrindole, or other delta-selective opioid antagonists, might be effective as medicines for use in treating cocaine abuse.

Original language	English (US)
Pages (from-to)	PL67-PL71
Journal	Life Sciences
Volume	52
Issue number	9
DOIs	https://doi.org/10.1016/0024-3205(93)90084-G
State	Published - 1993

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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10.1016/0024-3205(93)90084-G

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title = "Naltrindole, an opioid delta receptor antagonist, blocks cocaine-induced facilitation of responding for rewarding brain stimulation",

abstract = "Recent experimental results have led to the suggestion that opioid antagonists can modulate the reinforcing properties of cocaine. In this experiment, rats were fixed with chronically indwelling bipolar electrodes for stimulation of the medial forebrain bundle (MFB) as it courses through the hypothalamus. Rats were taught to press a lever for brief trains of electrical stimulation of the MFB. Subsequently, they were allowed to press for varying intensities of stimulation daily until their response rates were stable. Cocaine (5 mg/kg, s.c.) enhanced the rate of pressing for lower intensities of brain stimulation. Naltrindole (3 mg/kg, i.p.) had no effect on response rate alone but blocked the cocaine-induced facilitation of pressing for rewarding brain stimulation. An implication that can be drawn from these data is that naltrindole, or other delta-selective opioid antagonists, might be effective as medicines for use in treating cocaine abuse.",

author = "Reid, {Larry D.} and Hubbell, {Christopher L.} and Glaccum, {Matthew B.} and Bilsky, {Edward J.} and Portoghese, {Philip S.} and Frank Porreca",

note = "Funding Information: This rcscarch was supported,i n part, by a grant from the National lnstitutc of Drug Abuse (DA 04440). Some of the work associalcd with this project was a part of a rcscarch participation project associatedw ith the B.S. dcgrcc (M.G{\textquoteleft}.).",

year = "1993",

doi = "10.1016/0024-3205(93)90084-G",

language = "English (US)",

volume = "52",

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T1 - Naltrindole, an opioid delta receptor antagonist, blocks cocaine-induced facilitation of responding for rewarding brain stimulation

AU - Reid, Larry D.

AU - Hubbell, Christopher L.

AU - Glaccum, Matthew B.

AU - Bilsky, Edward J.

AU - Portoghese, Philip S.

AU - Porreca, Frank

N1 - Funding Information: This rcscarch was supported,i n part, by a grant from the National lnstitutc of Drug Abuse (DA 04440). Some of the work associalcd with this project was a part of a rcscarch participation project associatedw ith the B.S. dcgrcc (M.G‘.).

PY - 1993

Y1 - 1993

N2 - Recent experimental results have led to the suggestion that opioid antagonists can modulate the reinforcing properties of cocaine. In this experiment, rats were fixed with chronically indwelling bipolar electrodes for stimulation of the medial forebrain bundle (MFB) as it courses through the hypothalamus. Rats were taught to press a lever for brief trains of electrical stimulation of the MFB. Subsequently, they were allowed to press for varying intensities of stimulation daily until their response rates were stable. Cocaine (5 mg/kg, s.c.) enhanced the rate of pressing for lower intensities of brain stimulation. Naltrindole (3 mg/kg, i.p.) had no effect on response rate alone but blocked the cocaine-induced facilitation of pressing for rewarding brain stimulation. An implication that can be drawn from these data is that naltrindole, or other delta-selective opioid antagonists, might be effective as medicines for use in treating cocaine abuse.

AB - Recent experimental results have led to the suggestion that opioid antagonists can modulate the reinforcing properties of cocaine. In this experiment, rats were fixed with chronically indwelling bipolar electrodes for stimulation of the medial forebrain bundle (MFB) as it courses through the hypothalamus. Rats were taught to press a lever for brief trains of electrical stimulation of the MFB. Subsequently, they were allowed to press for varying intensities of stimulation daily until their response rates were stable. Cocaine (5 mg/kg, s.c.) enhanced the rate of pressing for lower intensities of brain stimulation. Naltrindole (3 mg/kg, i.p.) had no effect on response rate alone but blocked the cocaine-induced facilitation of pressing for rewarding brain stimulation. An implication that can be drawn from these data is that naltrindole, or other delta-selective opioid antagonists, might be effective as medicines for use in treating cocaine abuse.

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Naltrindole, an opioid delta receptor antagonist, blocks cocaine-induced facilitation of responding for rewarding brain stimulation

Abstract

ASJC Scopus subject areas

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