Nabilone: A potent antiemetic cannabinol with minimal euphoria

T. S. Herman; S. E. Jones; J. Dean; S. Leigh; R. Dorr; T. E. Moon; S. E. Salmon

Nabilone: A potent antiemetic cannabinol with minimal euphoria

T. S. Herman, S. E. Jones, J. Dean, S. Leigh, R. Dorr, T. E. Moon, S. E. Salmon

Research output: Contribution to journal › Article › peer-review

Abstract

Nabilone is a cannabinol derivative which has potent central antiemetic effects in animals. We observed that the drug significantly reduced the nausea and vomiting induced by cancer chemotherapy in 10 of 13 patients who were refractory to conventional antiemetics. A dose-response effect was apparent. The drug was generally well-tolerated, although it also had sedative effects. Additionally, dizziness, decreased coordination and postural hypotension were observed in some patients. Euphoric effects of the agent were minimal at antiemetic dosage levels.

Original language	English (US)
Pages (from-to)	331-334
Number of pages	4
Journal	Unknown Journal
Volume	27
Issue number	9-10
State	Published - 1977
Externally published	Yes

ASJC Scopus subject areas

General Medicine

Cite this

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title = "Nabilone: A potent antiemetic cannabinol with minimal euphoria",

abstract = "Nabilone is a cannabinol derivative which has potent central antiemetic effects in animals. We observed that the drug significantly reduced the nausea and vomiting induced by cancer chemotherapy in 10 of 13 patients who were refractory to conventional antiemetics. A dose-response effect was apparent. The drug was generally well-tolerated, although it also had sedative effects. Additionally, dizziness, decreased coordination and postural hypotension were observed in some patients. Euphoric effects of the agent were minimal at antiemetic dosage levels.",

author = "Herman, {T. S.} and Jones, {S. E.} and J. Dean and S. Leigh and R. Dorr and Moon, {T. E.} and Salmon, {S. E.}",

year = "1977",

language = "English (US)",

volume = "27",

pages = "331--334",

journal = "Unknown Journal",

issn = "0375-9474",

publisher = "Elsevier B.V.",

number = "9-10",

}

TY - JOUR

T1 - Nabilone

T2 - A potent antiemetic cannabinol with minimal euphoria

AU - Herman, T. S.

AU - Jones, S. E.

AU - Dean, J.

AU - Leigh, S.

AU - Dorr, R.

AU - Moon, T. E.

AU - Salmon, S. E.

PY - 1977

Y1 - 1977

N2 - Nabilone is a cannabinol derivative which has potent central antiemetic effects in animals. We observed that the drug significantly reduced the nausea and vomiting induced by cancer chemotherapy in 10 of 13 patients who were refractory to conventional antiemetics. A dose-response effect was apparent. The drug was generally well-tolerated, although it also had sedative effects. Additionally, dizziness, decreased coordination and postural hypotension were observed in some patients. Euphoric effects of the agent were minimal at antiemetic dosage levels.

AB - Nabilone is a cannabinol derivative which has potent central antiemetic effects in animals. We observed that the drug significantly reduced the nausea and vomiting induced by cancer chemotherapy in 10 of 13 patients who were refractory to conventional antiemetics. A dose-response effect was apparent. The drug was generally well-tolerated, although it also had sedative effects. Additionally, dizziness, decreased coordination and postural hypotension were observed in some patients. Euphoric effects of the agent were minimal at antiemetic dosage levels.

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UR - http://www.scopus.com/inward/citedby.url?scp=0017608116&partnerID=8YFLogxK

M3 - Article

C2 - 606307

AN - SCOPUS:0017608116

SN - 0375-9474

VL - 27

SP - 331

EP - 334

JO - Unknown Journal

JF - Unknown Journal

IS - 9-10

ER -

Nabilone: A potent antiemetic cannabinol with minimal euphoria

Abstract

ASJC Scopus subject areas

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